Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population.
Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population.
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使用经验数据比较 SNP 标记方法：染色体 12q14.3-12q24.21 上 713 个 SNP 与非洲加勒比人群哮喘和血清总 IgE 的关联研究。
DOI：
10.1002/gepi.20172
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发表时间：
2006
影响因子：
2.1
通讯作者：
Fallin,MDaniele
中科院分区：
文献类型：
--
作者：
Chi,PeterB;Duggal,Priya;Kao,WHLinda;Mathias,RasikaA;Grant,AudreyV;Stockton,MariaL;Garcia,JoeGN;Ingersoll,RoxannG;Scott,AlanF;Beaty,TerriH;Barnes,KathleenC;Fallin,MDaniele
一些比较研究已经进行了单核苷酸多态性（SNP）标记方法，以检查其一致性和有效性方面的推论与疾病的关联。我们应用了几种SNP标记的方法，染色体12 q（n=713）上的SNP，并比较了这些方法的效用，以检测哮喘和血清IgE水平之间的关联从巴巴多斯的非洲加勒比家庭的样本，通过哮喘先证者选择。我们发现，在克莱顿的htSNP，斯特拉姆的标签SNP，和德巴克的标签中保留了高水平的信息。我们还发现了TagSNP和Tagger之间的高度一致性。利用染色体12q上的这组713个SNP，我们的研究为未来复杂性状的研究提供了分析策略。Epidemiol.2006.© 2006 Wiley利斯公司
Few comparison studies have been performed on single nucleotide polymorphism (SNP) tagging methods to examine their consistency and effectiveness in terms of inferences about association with disease. We applied several SNP tagging methods to SNPs on chromosome 12q (n=713) and compared the utility of these methods to detect association for asthma and serum IgE levels among a sample of African Caribbean families from Barbados selected through asthmatic probands. We found that a high level of information regarding association is retained in Clayton's htSNP, Stram's TagSNP, and de Bakker's Tagger. We also found a high degree of consistency between TagSNP and Tagger. Using this set of 713 SNPs on chromosome 12q, our study provides insight towards analytic strategies for future studies of complex traits.Genet. Epidemiol.2006. © 2006 Wiley‐Liss, Inc.