Psychological responses to BRCA1 mutation testing: preliminary findings.

Psychological responses to BRCA1 mutation testing: preliminary findings.
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BRCA1 突变测试的心理反应:初步发现。

DOI:
10.1037//0278-6133.16.1.63
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发表时间:
1997
期刊:
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
影响因子:
--
通讯作者:
Nash,J
Nash,J
中科院分区:
--
文献类型:
--
作者:
Croyle,RT;Smith,KR;Botkin,JR;Baty,B;Nash,J

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研究人员对60名携带BRCA1基因突变的成年女性的短期心理反应进行了研究,这些突变与乳腺癌和卵巢癌的高风险有关。参与者是一个正在进行的基因检测对社会心理影响的前瞻性研究的大型亲属的成员。报告了完成测试前基线和测试后1-2周随访访谈的参与者的初步结果。通过事件影响量表(Impact of Event Scale)测量,与非携带者相比,基因突变携带者明显表现出更高水平的与测试相关的心理困扰。在没有癌症病史或癌症相关手术的突变携带者中观察到最高水平的测试相关焦虑。虽然测试后总体焦虑(状态焦虑)有所下降,但在随访中,携带者比非携带者更焦虑。(PsycINFO数据库记录(c) 2016 APA,版权所有)
The short-term psychological responses of 60 adult women tested for a BRCA1 gene mutation associated with a high risk of breast and ovarian cancer were investigated. Participants were members of a large kindred enrolled in an ongoing prospective study of the psychosocial impact of genetic testing. Initial results from participants who completed both the pretest baseline and the 1-2 week posttest follow-up interviews are reported. Gene mutation carriers manifested significantly higher levels of test-related psychological distress, as measured by the Impact of Event Scale, when compared with noncarriers. The highest levels of test-related distress were observed among mutation carriers with no history of cancer or cancer-related surgery. Although general distress (state anxiety) declined after testing, carriers were more distressed than noncarriers at follow-up.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
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