EPIDEMIOLOGY OF OTITIS-MEDIA DURING THE 1ST 7 YEARS OF LIFE IN CHILDREN IN GREATER BOSTON - A PROSPECTIVE, COHORT STUDY
EPIDEMIOLOGY OF OTITIS-MEDIA DURING THE 1ST 7 YEARS OF LIFE IN CHILDREN IN GREATER BOSTON - A PROSPECTIVE, COHORT STUDY
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DOI：
10.1093/infdis/160.1.83
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发表时间：
1989-07-01
影响因子：
6.4
通讯作者：
ROSNER, B
中科院分区：
文献类型：
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作者：
TEELE, DW;KLEIN, JO;ROSNER, B
为了确定急性中耳炎（AOM）的流行病学和中耳积液的持续时间，我们连续随访了出生后不久至7岁的儿童。由于一些儿童退出了研究，因此对877名观察至少1年的儿童的数据进行了分析; 698名观察至少3年，498名观察至7岁。到1岁时，62%的儿童的.gtoreq. 1例AOM，17% ≥3次发作;到3岁时，83% ≥1例AOM，46% ≥三集。发病高峰出现在生命的第二个6个月期间。AOM的风险显著增加（多变量分析）与男性、兄弟姐妹AOM复发史、AOM早期发生和非母乳喂养有关。AOM发作后持续数周至数月，持续时间较长的AOM与男性、兄弟姐妹耳部感染史和非母乳喂养有关。
To determine the epidemiology of acute otitis media (AOM) and duration of middle ear effusion (MEE), we followed consecutively enrolled children from shortly after birth until 7 y of age. Because some children dropped out of the study, data were analyzed for 877 children observed for at least 1 y; 698 were observed for at least 3 y, and 498 were observed until 7 y of age. By 1 y of age, 62% of the chidlren had .gtoreq. 1 episode of AOM and 17% had .gtoreq. 3 episodes; by 3 y of age, 83% had .gtoreq. 1 episode of AOM and 46% had .gtoreq. 3 episodes. The peak incidence occurred during the second 6-mo period of life. Significantly increased risk (by multivariate analysis) for AOM was associated with male gender, sibling history of recurrent AOM, early occurrence of AOM, and not being breast fed. MEE persisted after onset of AOM for weeks to months; prolonged duration of MEE was associated with male gender, sibling history of ear infection, and not being breast fed.