Influence of Age on the Compensatory Response in Growth and Function to Unilateral Nephrectomy 1
Influence of Age on the Compensatory Response in Growth and Function to Unilateral Nephrectomy 1
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年龄对单侧肾切除术生长和功能代偿反应的影响 1
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
J. Hayslett
中科院分区：
文献类型：
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作者：
J. Galla;T. Klein;J. Hayslett
在断奶大鼠(I组)和青壮年大鼠(II组)上研究了年龄对单侧肾切除后结构和功能反应的影响。尽管术后一周，I组的代偿性增长并不明显大于II组(44%比39%，p-NS)，但在4周后，I组和II组的肾质量分别增加了144%和66%(p<；.0001)。术后1wk时肾小球滤过率I组为875±92min/μ/gKW，4wk时为1176±67/gKW。这些数据表明，未成熟大鼠的代偿性生长幅度大于成年大鼠，功能适应与结构变化平行。
The effect of age on the structural and functional response to unilateral nephrectomy was studied in weanling (group I) and young adult (group II) rats. Although compensatory growth in group I was not significantly greater than in group II one week following surgery (44% vs 39%, p - NS), after 4 wk renal mass had increased 144% in group I and 66% in group II (p < .0001). Glomerular filtration rate per unit kidney mass at 1 wk post surgery was 875 ± 92 (mean ± SEM) μ1/min/gKW) in group I and 1132 ± 67 in group II (p - NS) and at 4 wk was 1176 ± 67 in group I and 1261 ± 67 in group II (p - NS). These data indicate that the magnitude of compensatory growth in immature rats is greater than in adults and that functional adaptation parallels the structural change.