Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population
Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population
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DOI：
10.1007/s00420-012-0819-8
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发表时间：
2013-11-01
影响因子：
3
通讯作者：
Satoh, Hiroshi
中科院分区：
文献类型：
--
作者：
Nakamoto, Mariko;Arisawa, Kokichi;Satoh, Hiroshi
以前的研究报告说，接触二恶英与一般人群患各种疾病的风险增加有关。这项研究的目的是检查血液中二恶英含量与过敏性疾病和其他疾病之间的关系。在2002-2010年期间，我们对居住在日本各地且未因职业接触二恶英的1,063名男性和1,201名女性（15-76岁）进行了横断面研究。采用同位素稀释高分辨率气相色谱/质谱分析空腹血液样本中多氯二苯并对二恶英（pcdd）、多氯二苯并呋喃（pcdf）和类二恶英多氯联苯（DL-PCBs）。我们通过问卷调查获得了有关生活方式和自述病史的信息。同时测量血压、血红蛋白A1c水平和血脂。采用多元logistic回归模型分析血液中二恶英水平与多种疾病之间的关系。在对潜在混杂因素进行调整后，pcdd / pcdf和总二恶英的毒性当量与特应性皮炎呈显著的负剂量反应关系。与参考组（第一四分位数）相比，总二恶英最高四分位数的校正优势比为0.26（95%可信区间为0.08-0.70）。随着血液中pcdd / pcdf、DL-PCBs和总二恶英的毒性当量的增加，男性高血压、糖尿病、高脂血症、痛风和女性妇科疾病的优势比显著增加。目前的研究结果表明，背景暴露于二恶英与特应性皮炎的风险降低有关。研究结果还支持了低水平接触二恶英与糖尿病、高血压和高脂血症风险增加有关的观点。
Previous studies reported that exposure to dioxins was associated with an increased risk of various diseases in general populations.The aim of this study was to examine the association between levels of dioxins in blood and allergic and other diseases.We conducted a cross-sectional study on 1,063 men and 1,201 women (aged 15-76 years), who were living throughout Japan and not occupationally exposed to dioxins, during 2002-2010. In fasting blood samples, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) were analyzed by isotope dilution high-resolution gas chromatography/mass spectrometry. We obtained information on life style and self-reported history of diseases using a questionnaire. Blood pressure, blood levels of hemoglobin A1c, and serum lipids were also measured. Multiple logistic regression models were used to analyze the association between dioxin levels in blood and various diseases.Toxic equivalents of PCDDs/PCDFs and total dioxins showed significant inverse dose-response relationships with atopic dermatitis, after adjustments for potential confounders. The highest quartile for total dioxins had an adjusted odds ratio of 0.26 (95 % confidence interval 0.08-0.70) compared to the reference group (first quartile). The odds ratios for hypertension, diabetes mellitus, hyperlipidemia, gout in men, and gynecologic diseases in women significantly increased with increasing toxic equivalents of PCDDs/PCDFs, DL-PCBs, and total dioxins in blood.The present findings suggest that background exposure to dioxins was associated with reduced risk of atopic dermatitis. The results also support the idea that low-level exposure to dioxins is associated with an increased risk of diabetes, hypertension, and hyperlipidemia.