Synthesis of 2-aryl-2H-tetrazoles via a regioselective [3+2] cycloaddition reaction.
Synthesis of 2-aryl-2H-tetrazoles via a regioselective [3+2] cycloaddition reaction.
复制标题
DOI：
10.1016/j.tetlet.2016.02.102
复制
发表时间：
2016-04-06
影响因子：
1.8
通讯作者：
Kamenecka TM
中科院分区：
文献类型：
--
作者：
Patouret R;Kamenecka TM
本文报道了芳烃重氮盐与三甲基硅基重氮甲烷的区域选择性环加成反应。合成了一系列2-芳基四唑类化合物，产率适中，官能团相容性好。此外，该环加成反应为合成多用途中间体2-芳基-5-溴四唑开辟了道路。
A regioselective cycloaddition reaction of arenediazonium salts with trimethylsilyldiazomethane is reported. A series of 2-aryltetrazoles were obtained in good to moderate yields with wide functional group compatibility. Furthermore, this cycloaddition reaction opens the way to build up the versatile intermediate 2-aryl-5-bromotetrazole.