Prenatal Exposure to Nonpersistent Chemical Mixtures and Offspring IQ and Emotional and Behavioral Problems.
Prenatal Exposure to Nonpersistent Chemical Mixtures and Offspring IQ and Emotional and Behavioral Problems.
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产前接触非持久性化学混合物与后代智商以及情绪和行为问题。
DOI：
10.1021/acs.est.1c04455
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发表时间：
2021
影响因子：
11.4
通讯作者：
Guxens,Mònica
中科院分区：
文献类型：
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作者：
vandenDries,MichielA;Ferguson,KellyK;Keil,AlexanderP;Pronk,Anjoeka;Spaan,Suzanne;Ghassabian,Akhgar;Santos,Susana;Jaddoe,VincentWV;Trasande,Leonardo;Tiemeier,Henning;Guxens,Mònica
产前暴露于非持久性化学品，如邻苯二甲酸酯，双酚和有机磷（OP）农药是无处不在的，并发生在混合物。到目前为止，调查这些暴露的神经发育后果的流行病学研究主要限于单一污染物模型。因此，我们研究了产前暴露于非持久性化学混合物与儿童智商以及情绪和行为问题之间的关联。数据来自782对母子。11邻苯二甲酸酯，双酚，和五个OP农药尿暴露生物标志物测量三次在怀孕期间和平均值。非语言智商，内化和注意力问题，攻击性行为和自闭症特征在儿童6岁时进行了评估。我们使用分位数g计算来估计混合物中所有化学物质每四分位数增加时每个结果的变化。接触混合物越多，非语言智商越低（与第一四分位数相比，第二四分位数分别为-4.0分（95%CI =-7.0，-1.0）、-5.5分（95%CI =-10.2，-0.9）和-4.6分（95%CI =-10.8，1.5））。这些结果主要由邻苯二甲酸酯混合物驱动。没有观察到与情绪和行为问题的关联。产前暴露于非持久性化学混合物与儿童非语言智商较低有关。妊娠期间接触化学混合物是普遍现象，可能影响神经发育。
Prenatal exposure to nonpersistent chemicals such as phthalates, bisphenols, and organophosphate (OP) pesticides is ubiquitous and occurs in mixtures. So far, epidemiological studies investigating neurodevelopmental consequences of these exposures have mainly been restricted to single-pollutant models. Thus, we studied the association between prenatal exposure to nonpersistent chemical mixtures and child IQ and emotional and behavioral problems. Data came from 782 mother–child pairs. Eleven phthalate, one bisphenol, and five OP pesticide urinary exposure biomarkers were measured three times during pregnancy and averaged. Nonverbal IQ, internalizing and attention problems, aggressive behavior, and autistic traits were assessed at child age 6 years. We used quantile g-computation to estimate the change in each outcome per quartile increase in all chemicals within the mixture. Higher exposure to the mixture was associated with lower nonverbal IQ (−4.0 points (95%CI = −7.0, −1.0), −5.5 points (95%CI = −10.2, −0.9), and −4.6 points (95%CI = −10.8, 1.5) for the second, third, and fourth quartile, respectively, compared to the first quartile). These results were mainly driven by the phthalate mixture. No association was observed with emotional and behavioral problems. Prenatal exposure to nonpersistent chemical mixtures was associated with lower nonverbal IQ in children. Exposure to chemical mixtures during gestation is universal and may impact neurodevelopment.