Depression Impairs Learning Whereas Anticholinergics Impair Transfer Generalization in Parkinson Patients Tested on Dopaminergic Medications
Depression Impairs Learning Whereas Anticholinergics Impair Transfer Generalization in Parkinson Patients Tested on Dopaminergic Medications
复制标题
DOI：
10.1097/wnn.0b013e3181df3048
复制
发表时间：
2010-06-01
影响因子：
1.4
通讯作者：
Gluck, Mark A.
中科院分区：
文献类型：
--
作者：
Herzallah, Mohammad M.;Moustafa, Ahmed A.;Gluck, Mark A.
在一项帕金森病(PD)获得性等价性研究中，患者接受了正常多巴胺能药物的测试，我们发现，合并临床抑郁会损害最初的获得性，而使用抗胆碱能药物则会损害随后的转移泛化。此外，这项研究复制了Myers等人(2003)的基本发现，即接受多巴胺能治疗的帕金森病患者在最初获得多巴胺治疗时受到损害，但在随后的转移推广中是正常的，将这些结果推广到讲阿拉伯语的人群，包括许多没有接受过正规教育的参与者。这些结果与我们过去的计算模型是一致的，该模型认为基于反馈的增量习得学习任务的获得依赖于皮质纹状体回路，而迁移概括依赖于内侧颞叶(MT)结构。它们还与先前的计算模型以及在人类和动物中的经验性工作相一致，表明抗胆碱能药物可能特别损害依赖MT叶的认知能力。
In a study of acquired equivalence in Parkinson disease (PD), in which patients were tested on normal dopaminergic medication, we found that comorbid clinical depression impairs initial acquisition, whereas the use of anticholinergic therapy impairs subsequent transfer generalization. In addition, this study provides a replication of the basic finding of Myers et al (2003) that patients with PD on dopaminergic therapy are impaired at initial acquisition, but normal at subsequent transfer generalization, generalizing these results to an Arabic-speaking population including many participants with no formal education. These results are consistent with our past computational modeling, which argues that acquisition of incrementally acquired, feedback-based learning tasks is dependent on cortico-striatal circuits, whereas transfer generalization is dependent on medial temporal (MT) structures. They are also consistent with prior computational modeling, and with empiric work in humans and animals, suggesting that anticholinergic drugs may particularly impair cognitive abilities that depend on the MT lobe.