Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: Updated recommendations from the World Health Organization Pneumococcal Carriage Working Group
Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: Updated recommendations from the World Health Organization Pneumococcal Carriage Working Group
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DOI：
10.1016/j.vaccine.2013.08.062
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发表时间：
2013-12-17
期刊：
影响因子：
5.5
通讯作者：
O'Brien, Katherine L.
中科院分区：
文献类型：
--
作者：
Satzke, Catherine;Turner, Paul;O'Brien, Katherine L.
2003年，世界卫生组织（WHO）召集了一个工作组，并发布了一套标准方法，用于测量鼻咽部肺炎链球菌（肺炎球菌）携带情况的研究。该工作组最近在世卫组织的主持下重新召开会议，并更新了共识标准方法。这些方法描述了鼻咽样本的收集、运输和储存，并为使用基于培养和非培养的方法进行肺炎球菌的鉴定和血清分型提供了建议。我们概述了工作组的共识立场，支持这一立场的证据，值得未来研究的领域，以及运输研究的流行病学作用。坚持这些方法将减少在肺炎球菌疫苗试验、实施研究和流行病学研究背景下进行的肺炎球菌携带研究的变异性，因此方法学的变异性不会混淆对研究结果的解释。(C)2013爱思唯尔有限公司版权所有。
In 2003 the World Health Organization (WHO) convened a working group and published a set of standard methods for studies measuring nasopharyngeal carriage of Streptococcus pneumoniae (the pneumococcus). The working group recently reconvened under the auspices of the WHO and updated the consensus standard methods. These methods describe the collection, transport and storage of nasopharyngeal samples, as well as provide recommendations for the identification and serotyping of pneumococci using culture and non-culture based approaches. We outline the consensus position of the working group, the evidence supporting this position, areas worthy of future research, and the epidemiological role of carriage studies. Adherence to these methods will reduce variability in the conduct of pneumococcal carriage studies undertaken in the context of pneumococcal vaccine trials, implementation studies, and epidemiology studies more generally so variability in methodology does not confound the interpretation of study findings. (C) 2013 Elsevier Ltd. All rights reserved.