Urinary and sexual outcomes in long-term (5+years) prostate cancer disease free survivors after radical prostatectomy
Urinary and sexual outcomes in long-term (5+years) prostate cancer disease free survivors after radical prostatectomy
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DOI：
10.1186/1477-7525-7-94
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发表时间：
2009-11-13
影响因子：
3.6
通讯作者：
Carini, Marco
中科院分区：
文献类型：
--
作者：
Gacci, Mauro;Simonato, Alchiede;Carini, Marco
背景：长期无病随访 (FUp) 后，患者重新考虑生活质量 (QOL) 结果。本研究的目的是评估根治性前列腺切除术 (RP) 后至少 5 年无病的前列腺癌患者的生活质量。方法：招募了 367 例接受 RP 治疗的临床局限性前列腺癌患者，无生化失败（PSA = 5 年）。使用 UCLA-PCI 问卷评估排尿（UF）和性功能（SF）、排尿（UB）和性骚扰（SB）。 根据以下因素对 UF、UB、SF 和 SB 进行分析：治疗时机（RP 时的年龄、FUp 持续时间、FUp 时的年龄）、肿瘤特征（术前 PSA、TNM 分期、病理格里森评分）、神经保留 (NS) 手术和激素治疗 (HT)。我们计算了 93 例未进行 HT 的 NS-RP（A 组）与 274 例未进行 HT 的 NS-RP 或 274 例非 NS-RP 或激素治疗之间的差异。 NS-RP 与 HT（B 组）。我们根据随访持续时间评估A组功能和烦恼之间的相关性。结果：前列腺切除术后的时间对SF有负面影响，对SB有正面影响（均p < 0.001）。老年男性在随访中经历了更差的 UF 和 SF（p = 0.02 和 p < 0.001）和更好的 SB（p < 0.001）。较高阶段的 PCa 对 UB 产生负面影响， SF 和 SB（全部：p
Background: After long term disease free follow up (FUp) patients reconsider quality of life (QOL) outcomes. Aim of this study is assess QoL in prostate cancer patients who are disease-free at least 5 years after radical prostatectomy (RP).Methods: 367 patients treated with RP for clinically localized pCa, without biochemical failure (PSA = 5 years were recruited.Urinary (UF) and Sexual Function (SF), Urinary (UB) and Sexual Bother (SB) were assessed by using UCLA-PCI questionnaire. UF, UB, SF and SB were analyzed according to: treatment timing (age at time of RP, FUp duration, age at time of FUp), tumor characteristics (preoperative PSA, TNM stage, pathological Gleason score), nerve sparing (NS) procedure, and hormonal treatment (HT).We calculated the differences between 93 NS-RP without HT (group A) and 274 non-NS-RP or NS-RP with HT (group B). We evaluated the correlation between function and bother in group A according to follow-up duration.Results: Time since prostatectomy had a negative effect on SF and a positive effect SB (both p < 0.001). Elderly men at follow up experienced worse UF and SF (p = 0.02 and p < 0.001) and better SB (p < 0.001).Higher stage PCa negatively affected UB, SF, and SB (all: p