Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: Effects of dietary fat content and sustained weight loss
Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: Effects of dietary fat content and sustained weight loss
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DOI：
10.1210/jc.81.12.4406
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发表时间：
1996-12-01
影响因子：
5.8
通讯作者：
Stern, JS
中科院分区：
文献类型：
--
作者：
Havel, PJ;KasimKarakas, S;Stern, JS
瘦素是肥胖(ob/ob)小鼠体内有缺陷的oh基因的人类同源产物，它可能是人类肥胖的体液调节因子。用放射免疫法测定了19例正常体重[体重指数(BMI)=24.5+/-0.6 kg/m(2)]和19例超重至肥胖(BMI=34.7+/-1.2 kg/m(2))非糖尿病绝经后妇女的血浆瘦素水平。此后，受试者吃非常低脂肪的饮食(
Leptin, the product of the human homologue of the oh gene, which is defective in the obese (ob/ob) mouse, may be a humoral regulator of human adiposity. Plasma leptin concentrations were measured by RIA in 19 normal weight [body mass index (BMI) = 24.5 +/- 0.6 kg/m(2)] and 19 overweight to obese (BMI = 34.7 +/- 1.2 kg/m(2)) nondiabetic postmenopausal women on sequential controlled weight-maintaining diets containing 31%, 23%, and 14% of energy as fat, each for 4-6 weeks. Thereafter, the subjects ate a very low fat diet (