NH+4 excretion by the dog during development of chronic acidosis.
NH+4 excretion by the dog during development of chronic acidosis.
复制标题
狗在慢性酸中毒过程中的NH 4 排泄。
DOI：
10.1159/000411209
复制
发表时间：
1985
影响因子：
--
通讯作者：
Simpson,DP
中科院分区：
文献类型：
--
作者：
Simpson,DP
酸中毒期间尿液中 NH 排泄的变化长期以来一直引起肾脏病学家和生理学家的兴趣，因为它们与伴随的肾脏代谢变化密切相关。人、大鼠和狗在这一领域受到青睐，因为每个物种在代谢性酸中毒时，NH 排泄量都会增加很多倍。最近，人们对比较代谢性或呼吸性酸中毒期间 NH 排泄和氨生成的相对变化产生了兴趣。令人惊讶的是，尽管几十年来对人、狗和大鼠进行了许多酸碱稳态研究，但对于这三个物种中的每一个，关于慢性酸中毒发展过程中 NH 排泄和尿液 pH 值变化的时间过程的信息都是不完整的。在人类中，自从 Sartorius 等人的早期研究以来，代谢性酸中毒发生时这些变化的时间进程已众所周知[1]。然而，人类呼吸性酸中毒发生过程中尿液 pH 值和 NH 排泄变化的信息尚缺乏。一项研究仔细评估了大鼠对代谢性酸中毒的适应能力[2]；仍需获得对呼吸性酸中毒反应的详细信息。在狗中，很少有可靠的数据描述代谢性酸中毒最初几天 NH 排泄和尿液 pH 值的日常变化 [3]。相比之下，在狗适应慢性呼吸性酸中毒期间这些测量值的变化已有令人满意的数据[4, 5]。
Changes in NH excretion in the urine during acidosis have long interested nephrologists and physiologists because of their close relationship to accompanying alterations in renal metabolism. Man, rat and dog have been favored for study in this area because each species shows a manyfold increase in NH excretion in response to metabolic acidosis. Recently, in-terest has developed in comparing the relative changes in NH excretion and in ammoniagenesis during metabolic or respiratory acidosis. Surpris-ingly, despite the many studies of acid-base homeostasis carried out during several decades in man, dog and rat, information is incomplete in each of these three species on the time course of changes in NH excretion and urine pH during development of chronic acidosis. In man, the time course of these changes when metabolic acidosis develops has been well known since the early studies of Sartorius et al.[1]. However, information on changes in urine pH and NH excretion during development of respiratory acidosis is lacking in man. In rat, one study has carefully evaluated the adaptation to metabolic acidosis [2]; details of the response to respiratory acidosis still need to be obtained. In dog, little re-liable data has been published describing day-to-day changes in NH ex-cretion and urine pH during the initial days of metabolic acidosis [3]. In contrast, satisfactory data are available in dog for changes in these measure-ments during adaptation to chronic respiratory acidosis [4, 5].