Physical and chemical properties of an antimicrobial Bis-GMA free dental resin with quaternary ammonium dimethacrylate monomer
Physical and chemical properties of an antimicrobial Bis-GMA free dental resin with quaternary ammonium dimethacrylate monomer
复制标题
DOI：
10.1016/j.jmbbm.2015.10.028
复制
发表时间：
2016-03-01
影响因子：
3.9
通讯作者：
Vallittu, Pekka K.
中科院分区：
文献类型：
--
作者：
Huang, Qi-ting;He, Jing-wei;Vallittu, Pekka K.
本研究的目的是评价二甲基丙烯酸季铵盐单体N的抗菌活性、理化性质，N-二[2-（3-（甲基丙烯酰氧基）丙酰胺基）-乙基]-N-甲基十六烷基溴化铵（IMQ-16）/三环癸烷二甲醇二丙烯酸酯（SR 833 s）树脂体系，并与双苯基缩水甘油基二甲基丙烯酸酯（Bis-GMA）/三甘醇二甲基丙烯酸酯（TEGDMA）树脂体系进行比较树脂体系假设实验聚合物的物理和化学性能与Bis-GMA/TEGDMA聚合物相当，并且IMQ-16单体可以赋予UDMA/SR 833 s树脂抗菌活性。使用傅里叶变换红外光谱（FTIR）测量双键转化率（DC）。采用2 mm × 2 mm × 25 mm的棒进行三点弯曲试验，测定其弯曲强度（FS）和弯曲模量（FM）等力学性能，并研究其吸水性（WS）和溶解性（WSL）。所获得的聚合物对变形链球菌的抗细菌活性。通过直接接触试验（DCT）检测变形杆菌（mutans）。还通过琼脂扩散试验（ADT）研究了可溶性组分的抗菌活性。所有含有顶Q-16的聚合物都表现出WS和WSL的改善，同时相对于BisGMA/TEGDMA对照体系保持等同的DC和FS。将17%和20%的IMQ-16掺入UDMA/SR 833 s树脂中可降低S.在ADT中，孵育后在材料表面上产生了变形杆菌，并且在固化的圆盘周围没有产生抑制区。UDMA/SR 833 s树脂体系有望配制具有与Bis-GMA/TEGDMA配方相当甚至更高的物理化学性质的抗菌聚合物。当IMQ-16的质量分数为17%或20%时，可赋予UDMA/SR 833 s树脂体系显著的抗菌活性。(C)2015爱思唯尔有限公司版权所有。
The objective of this study was to evaluate the antibacterial activity, physicochemical properties of the quaternary ammonium dimethacrylate monomer N,N-bis[2-(3-(methacryloyloxy)propanamido)-ethyl]-N-methylhexadecyl ammonium bromide (IMQ-16) containing diurethane dimethacrylate (UDMA)/tricyclodecane dimethanol diacrylate (SR833s) resin system and compare with bisphenylglycidyl dimethacrylate (Bis-GMA)/triethylene glycol dimethacrylate (TEGDMA) resin system. It was hypothesized that the physical and chemical properties of the experimental polymers would be comparable with Bis-GMA/TEGDMA polymer and IMQ-16 monomer could endow the UDMA/SR833s resin with antibacterial activity. Double bond conversion (DC) was measured using Fourier transform infrared spectroscopy (FTIR). Mechanical properties including flexural strength (FS) and flexural modulus (FM) were measured by three-point bending test with bars of 2 mm x 2 mm x 25 mm. Water sorption (WS) and solubility (WSL) were also investigated. Antibacterial activity of obtained polymers against Streptococcus mutans Ingbitt (S. mutans) was tested through direct contact test (DCT). The presence of antibacterial activity due to soluble components was also investigated by agar diffusion test (ADT). All of the polymers containing IMQ-16 exhibited improvements in WS and WSL, while maintaining equivalent DC and FS relative to the BisGMA/TEGDMA control system. Incorporation of 17% and 20% of IMQ-16 into UDMA/SR833s resin reduced the viable counts of S. mutans after incubation on the surface of the materials and produced no inhibition zones around the cured discs in ADT. UDMA/SR833s resin system is promising to formulate an antibacterial polymer with equivalent or even higher physicochemical properties relative to Bis-GMA/TEGDMA formulation. IMQ-16 is capable to endow UDMA/SR833s resin system with significant antibacterial activity when the mass ratio is 17% or 20%. (C) 2015 Elsevier Ltd. All rights reserved.