Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart
Prostacyclin is the major prostaglandin released from the isolated perfused rabbit and rat heart
复制标题
前列环素是从离体灌注兔和大鼠心脏中释放的主要前列腺素
作者：
E. A. de Deckere;D. Nugteren;F. TEN HOOR
前列环素（前列腺素X，PGI 2）是一种新发现的前列腺素1 -3，由几种器官的微粒体（如猪和兔的胃2和大鼠胃4）以及新鲜的人动脉和静脉组织与PGH 2孵育后形成（参考文献5）。作为血小板聚集的抑制剂，它比PGE 1强30倍（参考文献2），因此有助于防止动脉内血栓的形成。已证实1，血小板释放的内过氧化物可被血管组织转化为前列环素。前列环素在水溶液中化学性质不稳定：它水解为6-氧代-PGF 1 α（参考文献3、4;图1），不抑制血小板聚集2。我们报告说，离体灌注兔和大鼠心脏产生一个不稳定的因素，强烈抑制血小板聚集，这种物质的释放被吲哚美辛废除。使用物理化学方法，我们在灌注液中发现了大量的6-oxo-PGF 1 α。这些发现表明前列环素是心脏释放的主要前列腺素。
PROSTACYCLIN (prostaglandin X, PGI2), a newly discovered prostaglandin1–3, is formed by microsomes from several organs, such as pig and rabbit aorta2 and rat stomach4, and by fresh human arterial and venous tissue incubated with PGH2 (ref. 5). As inhibitor of blood platelet aggregation, it is 30 times more potent than PGE1 (ref. 2) and could thus help in preventing the formation of intra-arterial thrombi. It has been suggested1 that the endoperoxides released by the platelets can be converted into prostacyclin by vascular tissue. Prostacyclin is chemically unstable in aqueous solution: it hydrolyses to 6-oxo-PGF1α (refs 3, 4; Fig. 1) which does not inhibit platelet aggregation2. We report that isolated perfused rabbit and rat hearts produce a labile factor which strongly inhibits blood platelet aggregation; the release of this substance is abolished by indomethacin. Using a physicochemical method, we found 6-oxo-PGF1α in substantial amounts in the perfusates. These findings indicate that prostacyclin is the major prostaglandin released from the heart.