Cerebral venous oxygen content as a measure of brain energy metabolism with increased intracranial pressure and hyperventilation.
Cerebral venous oxygen content as a measure of brain energy metabolism with increased intracranial pressure and hyperventilation.
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DOI：
10.3171/jns.1990.73.6.0927
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发表时间：
1990-12
影响因子：
4.1
通讯作者：
L. Sutton;A. McLaughlin;S. Dante;M. Kotapka;T. Sinwell;E. Mills
中科院分区：
文献类型：
--
作者：
L. Sutton;A. McLaughlin;S. Dante;M. Kotapka;T. Sinwell;E. Mills
为了验证脑动静脉氧分压差（AVDO 2）和静脉氧含量（VO 2）可用于颅内压（ICP）升高时脑能量代谢监测的假设。本文对12只猫进行了~（31）P磁共振波谱研究。通过脑池灌注盐水使六只猫经受颅内高压。在平均AVDO 2为8.4 +/- 3.2 vol%（+/-标准差）（范围为4.7 - 14.7 vol%）时发生能量故障。代谢衰竭点的VO 2平均为1.45 +/- 0.6 vol%，并在较窄的范围内（1.0至2.9 vol%）延伸。在另外6只猫中，ICP升高至代谢衰竭阈值，然后开始过度通气（pCO 2 10 - 18 μ l）。6只猫中有5只出现VO 2下降伴换气过度。在其中两只动物中，过度换气导致VO 2为1.1 vol%或更低，并导致代谢衰竭，如磷酸肌酸下降所证明。得出的结论是，VO 2小于2 vol%与脑缺血相关，并且可以通过使用VO 2来监测在ICP增加的情况下过度通气的安全性。
In order to test the hypothesis that the cerebral arteriovenous oxygen difference (AVDO2) and venous oxygen content (VO2) could be used to monitor brain energy metabolism in the setting of increased intracranial pressure (ICP). 12 cats were studied with 31P-magnetic resonance spectroscopy. six cats were subjected to intracranial hypertension by cisternal infusion of saline. Energy failure occurred at an average AVDO2 of 8.4 +/- 3.2 vol% (+/- standard deviation) (range 4.7 to 14.7 vol%). The VO2 at the point of metabolic failure averaged 1.45 +/- 0.6 vol% and extended over a narrower range (1.0 to 2.9 vol%). In an additional six cats, ICP was raised to the threshold of metabolic failure and hyperventilation was then instituted (pCO2 10 to 18 torr). Five of the six cats experienced a drop in VO2 with hyperventilation. In two of these animals, hyperventilation resulted in a VO2 of 1.1 vol% or less and in metabolic failure as evidenced by a fall in phosphocreatine. It is concluded that a VO2 of less than 2 vol% is correlated with brain ischemia and that the safety of hyperventilation in the setting of increased ICP can be monitored by the use of VO2.