MicroRNA-34a: Role in Cancer and Cardiovascular Disease
MicroRNA-34a: Role in Cancer and Cardiovascular Disease
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MicroRNA-34a：在癌症和心血管疾病中的作用
DOI：
10.2174/1389450115666140120102935
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发表时间：
2014-04-01
影响因子：
3.2
通讯作者：
Zhou, Jian-Ying
中科院分区：
文献类型：
--
作者：
Chen, Xi;Zhou, Jian-Ya;Zhou, Jian-Ying
小的非编码microRNA（miRNAs）在转录后和翻译水平上调节基因表达。失调的miRNAs参与了包括癌症和心血管疾病在内的多种疾病。MiR-34 a是在多种类型的癌症中下调的最多的抗肿瘤miR之一。它调节参与癌症发生、进展和转移的广泛基因和途径。除了癌症之外，最近发现miR-34 a作为一个损害因素与心血管疾病有关。在这篇综述中，我们强调了miR-34 a在癌症和心血管疾病中的复杂作用，以及治疗潜力。
Small non-coding microRNAs (miRNAs) regulate gene expression at the post-transcriptional and translational levels. The dysregulated miRNAs are involved in a large variety of diseases including cancer and cardiovascular diseases. MiR-34a is one of the most anti-oncomiRs that is down-regulated in multiple types of cancer. It regulates a wide range of genes and pathways involved in cancer initiation, progression and metastasis. Next to cancer, miR-34a is recently found to be implicated in cardiovascular disease as one damager factor. In this review, we highlight the complex roles of miR-34a in cancer and cardiovascular disease, as well as the therapeutic potentials.