Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer's Disease?
Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer's Disease?
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DOI：
10.1016/j.neuron.2016.08.027
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发表时间：
2016-09-07
期刊：
影响因子：
16.2
通讯作者：
Kipnis J
中科院分区：
文献类型：
--
作者：
Louveau A;Da Mesquita S;Kipnis J
淋巴管系统排出组织间液，其中包含组织的废物，并确保组织的免疫监视，允许免疫细胞再循环。直到最近，中枢神经系统（CNS）被认为是缺乏传统的淋巴管系统。最近在脑膜中发现了引流CNS的淋巴网络，这对从CNS引流大分子和免疫细胞的经典模型提出了质疑。在神经系统疾病的背景下，存在引流CNS的淋巴系统可能为治疗提供新的参与者和新的途径。在这篇综述中，我们将试图整合已知的主要功能的组织淋巴管存在于外周器官与脑膜淋巴管在神经系统疾病，特别是多发性硬化症和阿尔茨海默病的拟议功能。我们建议这些（以及潜在的其他）神经系统疾病可以被视为具有神经-淋巴-血管成分的疾病，并且应该作为治疗靶点。
Lymphatic vasculature drains interstitial fluids, which contain the tissue’s waste products and ensures immune surveillance of the tissues, allowing immune-cell recirculation. Until recently the central nervous system (CNS) was considered to be devoid of a conventional lymphatic vasculature. The recent discovery in the meninges of a lymphatic network that drains the CNS calls into question classic models for the drainage of macromolecules and immune cells from the CNS. In the context of neurological disorders, the presence of a lymphatic system draining the CNS potentially offers a new player and a new avenue for therapy. In this review, we will attempt to integrate the known primary functions of the tissue lymphatic vasculature that exists in peripheral organs with the proposed function of meningeal lymphatic vessels in neurological disorders, specifically multiple sclerosis and Alzheimer’s disease. We propose that these (and potentially other) neurological afflictions can be viewed as diseases with neuro-lympho-vascular component and should be therapeutically targeted as such.
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