Supramolecular organization of bacterial aerobic respiratory chains: From cells and back
Supramolecular organization of bacterial aerobic respiratory chains: From cells and back
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DOI：
10.1016/j.bbabio.2015.11.001
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发表时间：
2016-03-01
影响因子：
4.3
通讯作者：
Teixeira, Miguel
中科院分区：
文献类型：
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作者：
Melo, Ana M. P.;Teixeira, Miguel
来自所有生命王国的有氧呼吸链由几个复合体组成，这些复合体以其孤立的形式被深深地描述。这些膜复合物将还原底物的氧化与分子氧的还原联系起来，在线粒体或原核细胞质膜两侧之间的离子移位过程中保存能量。近年来，越来越多的证据表明，这些复合物被组织为超分子结构，即所谓的超复合物和微囊体，可用于真核生物强有力的数据，即通过电子显微镜和单粒子分析获得。基于蓝色天然凝胶和质谱分析，对原核生物进行了平行研究，表明在这些更简单的单细胞生物中也存在这种超复合物，不仅涉及典型的有氧呼吸相关复合物，而且还涉及厌氧相关酶。在对真核生物超复合体的数据进行简短概述之后，我们将全面分析迄今为止在细菌和古细菌中提出的不同类型的原核生物有氧呼吸超复合体。本文是由Conrad Mullineaux教授编辑的题为细菌生物能量系统的组织和动力学的特刊的一部分。(C)2015 Elsevier B.V.版权所有。
Aerobic respiratory chains from all life kingdoms are composed by several complexes that have been deeply characterized in their isolated form. These membranous complexes link the oxidation of reducing substrates to the reduction of molecular oxygen, in a process that conserves energy by ion translocation between both sides of the mitochondrial or prokaryotic cytoplasmatic membranes. In recent years there has been increasing evidence that those complexes are organized as supramolecular structures, the so-called supercomplexes and respirasomes, being available for eukaryotes strong data namely obtained by electron microscopy and single particle analysis. A parallel study has been developed for prokaryotes, based on blue native gels and mass spectrometry analysis, showing that in these more simple unicellular organisms such supercomplexes also exist, involving not only typical aerobic-respiration associated complexes, but also anaerobic-linked enzymes. After a short overview of the data on eukaryotic supercomplexes, we will analyse comprehensively the different types of prokaryotic aerobic respiratory supercomplexes that have been thus far suggested, in both bacteria and archaea. This article is part of a Special Issue entitled Organization and dynamics of bioenergetic systems in bacteria, edited by Prof Conrad Mullineaux. (C) 2015 Elsevier B.V. All rights reserved.