Small molecule inhibitors of anthrax lethal factor toxin.
Small molecule inhibitors of anthrax lethal factor toxin.
复制标题
炭疽致死因子毒素的小分子抑制剂。
DOI：
10.1016/j.bmc.2013.11.009
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发表时间：
2014
影响因子：
3.5
通讯作者：
Peet,NortonP
中科院分区：
文献类型：
--
作者：
Williams,JohnD;Khan,AtiyyaR;Cardinale,StevenC;Butler,MichelleM;Bowlin,TerryL;Peet,NortonP
This manuscript describes the preparation of new small molecule inhibitors ofBacillus anthracislethal factor. Our starting point was the symmetrical, bis-quinolinyl compound1(NSC 12155). Optimization of one half of this molecule led to new LF inhibitors that were desymmetrized to afford more drug-like compounds.
