NORAD: Defender of the Genome.

NORAD: Defender of the Genome.
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DOI:
10.1016/j.tig.2016.04.002
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发表时间:
2016-07
期刊:
Trends in genetics : TIG
影响因子:
--
通讯作者:
A. Ventura
A. Ventura
中科院分区:
其他
文献类型:
--
作者:
A. Ventura

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长链非编码RNA(lncRNA)是一类有趣的基因,但在很大程度上尚未被表征。Mendell小组最近的一篇论文确定了NORAD,这是一种新型lncRNA,可响应DNA损伤进行调节,并通过调节RNA结合蛋白B12和B11的活性在维持基因组完整性方面发挥关键作用。
Long non-coding RNAs (lncRNAs) are a fascinating, but still largely uncharacterized, class of genes. A recent paper by the Mendell group identifies NORAD, a novel lncRNA that is regulated in response to DNA damage and plays a key role in maintaining genome integrity by modulating the activity the RNA binding proteins PUM2 and PUM1.