Applied molecular genetics: new tools for microbiologists and clinicians.
Applied molecular genetics: new tools for microbiologists and clinicians.
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应用分子遗传学：微生物学家和临床医生的新工具。
DOI：
10.1093/infdis/153.3.416
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Engleberg,NC
中科院分区：
文献类型：
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作者：
Eisenstein,BI;Engleberg,NC
“我相信生物学研究可以为尽可能多的人提供令人满意的职业，但我不认为生物学研究对医学或技术的传统好处在未来会很普遍。似乎不太可能出现全新的治疗原则。我们必须放弃我们过去在学者中声称的特殊地位，即我们的工作具有特殊的美德，因为它有拯救生命的潜力。伯内特爵士[1]也许没有什么比1971年和现在关于基础科学和应用研究在我们治疗人类疾病的方法中的效用的前景上的差异更能戏剧性地说明应用分子遗传学的快速发展。这一速度是爆炸性的（见表1）。我们现在正处于诊断和预防许多传染病的革命的门槛。这场革命背后的驱动力是应用基因工程工具来解决微生物学问题。半个世纪前开始的试图通过研究微生物的基本性质来揭开生命的秘密的尝试，导致了对所有生命形式的普遍原则的理解。这些原则现在被应用于医学的许多层面，具有讽刺意味的是，包括控制由相同微生物引起的疾病
" I believe that biological research can provide gratifying oc-cupation for as many people as have the necessary training [but] I do not expect conventional benefits to medicine or technology from biological research to be common in the future... It does not seem likely that wholly new principles of treatment will emerge... We [doing medical research] shall have to forego that special place we used to claim amongst scholars that there was special virtue in our work because of its potentiality for saving life." Sir Frank MacFarlane Burnet [1]Perhaps nothing dramatizes the rapidity of development of applied molecular genetics more than the difference in outlook in 1971 and now concerning the utility of basic science and applied research in our approach to human disease. The pace has been explosive (see table 1). We are now poised at the threshold of a revolution in the diagnosis and preven-tion of many infectious diseases. The driving force behind this revolution is the application of the tools of genetic engineering to solve problems of microbiology. What began a half century ago as an attempt to unravel the secrets of life by examining the fundamental nature of microorganisms has led to the appreciation of universal principles of all life forms. Such principles are now being employed at many levels of medicine including, ironically, the control of diseases caused by the very same microorganisms