TOLYTOXIN AND NEW SCYTOPHYCINS FROM 3 SPECIES OF SCYTONEMA
TOLYTOXIN AND NEW SCYTOPHYCINS FROM 3 SPECIES OF SCYTONEMA
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DOI：
10.1021/np50072a021
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发表时间：
1990-11-01
影响因子：
5.1
通讯作者：
PATTERSON, GML
中科院分区：
文献类型：
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作者：
CARMELI, S;MOORE, RE;PATTERSON, GML
Tolytoxin [1]是与奇异Scytonema mirabile菌株BY-8-1、缅甸Scytonema burmanicum菌株DO-4-1和眼斑Scytonema ocellatum菌株DD-8-1、FF-65-1和FF-66-3相关的主要细胞毒素，已被证明是6-羟基-7-0-甲基scytophycin B。少量的其他三种新的细胞毒性scytophycin，6-hydroxyscytophycin B [2]，19-0-demethylscytophycin C [3]，和6-hydroxy-7-0-methylscytophycin E [4]，也已经从这些蓝藻中分离出来。其结构和立体化学是基于核磁共振和cd分析以及与scytophycins A-E的比较。
Tolytoxin [1], the major cytotoxin associated with Scytonema mirabile strain BY-8-1, Scytonema burmanicum strain DO-4-1 and Scytonema ocellatum strains DD-8-1, FF-65-1, and FF-66-3, has been shown to be 6-hydroxy-7-0-methylscytophycin B. Minor amounts of three other new cytotoxic scytophycins, 6-hydroxyscytophycin B [2], 19-0-demethylscytophycin C [3], and 6-hydroxy-7-0-methylscytophycin E [4], have also been isolated from these cyanophytes. The gross structures and stereochemistry are based on nmr and cd analysis and on comparison with scytophycins A-E.