Copper-Catalyzed Diamination of Unactivated Alkenes With Electron-Rich Amino Sources
Copper-Catalyzed Diamination of Unactivated Alkenes With Electron-Rich Amino Sources
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DOI：
10.1021/acs.orglett.1c01313
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发表时间：
2021-05-10
期刊：
影响因子：
5.2
通讯作者：
Fu, Junkai
中科院分区：
文献类型：
--
作者：
Li, Yang;Ali, Arshad;Fu, Junkai
未活化烯烃与富电子氨基源的催化分子间二胺化是一个挑战。在此，通过采用导向基团策略，实现了铜催化未活化烯烃的二胺化。对称的二胺有效地生产在一个高度非对映选择性的方式与容易获得的二烷基胺作为氨基源，而一锅和两步操作是必要的，以生产不对称的二胺。提出这些反应通过氮丙啶中间体进行。
The catalytic intermolecular diamination of unactivated alkenes with electron-rich amino sources is a challenge. Herein, by employing a directing-group strategy, a copper-catalyzed diamination of unactivated alkenes was realized. Symmetrical diamines were efficiently produced in a highly diastereoselective manner with readily available dialkylamines as amino sources, while a one-pot and two-step operation was necessary to produce the unsymmetrical diamines. These reactions were proposed to proceed through aziridinium intermediates.