SYNTHESIS AND LABORATORY EVALUATION OF 1-(2,6-DISUBSTITUTED BENZOYL)-3-PHENYLUREAS, A NEW CLASS OF INSECTICIDES .1. 1-(2,6-DICHLOROBENZOYL)-3-PHENYLUREAS
SYNTHESIS AND LABORATORY EVALUATION OF 1-(2,6-DISUBSTITUTED BENZOYL)-3-PHENYLUREAS, A NEW CLASS OF INSECTICIDES .1. 1-(2,6-DICHLOROBENZOYL)-3-PHENYLUREAS
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DOI：
10.1021/jf60187a052
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发表时间：
1973-01-01
影响因子：
6.1
通讯作者：
VANDAALE.JJ
中科院分区：
文献类型：
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作者：
WELLINGA, K;MULDER, R;VANDAALE.JJ
在发现L-(2，6-二氯苯甲酰基)-3-(3，4-二氯苯基)-尿素(DU 19111)具有很强的杀幼虫活性后，合成了大量的结构类似物。以埃及斑潜蝇、菜粉蝶和十字斑潜蝇幼虫为研究对象，对其杀虫性能进行了评价。事实证明，这些化合物中的许多都是很好的杀虫剂，产生了与DU 19111相同的症状。这些症状表明角质层沉积过程紊乱，导致流产蜕皮。在L-(2，6-二氯苯甲酰基)-3-苯基脲系列化合物中，3-(4-氯苯基)衍生物(PH60-38)是最有前途的化合物。
Upon the discovery of the powerful larvicidal properties of l-(2, 6-dichlorobenzoyl)-3-(3, 4-dichlorophenyl)-urea (DU 19111), a large number of structural analogs were prepared. Their insecticidal properties were evaluated with larval stages of Aédes aegypti L., Pieris brassicae L., and Leptinotarsa decemlineata Say. Many of these compounds proved to be excellent insecticides, bringing about the same symptoms as DU 19111. These symptoms are indicative of a disturbance of the process of cuticle deposition, resulting in abortive moult. Within the series of l-(2, 6-dichlo-robenzoyl)-3-phenylureas, the 3-(4-chlorophenyl)-derivative (PH 60-38) appeared to be the most promising compound for several fieldsof applica-tion.