Knee joint preservation with combined neutralising High Tibial Osteotomy (HTO) and Matrix-induced Autologous Chondrocyte Implantation (MACI) in younger patients with medial knee osteoarthritis: A case series with prospective clinical and MRI follow-up over 5 years
Knee joint preservation with combined neutralising High Tibial Osteotomy (HTO) and Matrix-induced Autologous Chondrocyte Implantation (MACI) in younger patients with medial knee osteoarthritis: A case series with prospective clinical and MRI follow-up over 5 years
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DOI：
10.1016/j.knee.2011.06.005
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发表时间：
2012-08-01
期刊：
影响因子：
1.9
通讯作者：
Wood, D. J.
中科院分区：
文献类型：
--
作者：
Bauer, S.;Khan, R. J. K.;Wood, D. J.
目的：对于年轻的膝关节内侧骨关节炎（OA）和内翻错位患者没有理想的治疗方法。我们用MRI研究了第一例联合中和胫骨高位截骨术（HTO）和基质诱导的自体软骨细胞植入（MACI）。治疗目标是临床改善和延缓关节置换术。方法：2002 ~ 2005年间，18例患者接受手术治疗，平均年龄47岁。排除标准为外侧腔室和晚期髌骨骨关节炎。膝关节损伤和骨关节炎结局评分（oos）、6分钟步行测试（6MWT）和有效的MRI评分是结局测量指标。结果：两组患者均有显著改善(p
Purpose: There is no ideal treatment for younger patients with medial knee osteoarthritis (OA) and varus malalignment. We have investigated the first case series of combined neutralising high tibial osteotomy (HTO) and Matrix-induced Autologous Chondrocyte Implantation (MACI) with MRI. Treatment goals were clinical improvement and delay of arthroplasty.Methods: Between 2002 and 2005 18 patients (Mean age 47 years) underwent surgery. Exclusion criteria were lateral compartment and advanced patellofemoral OA. The Knee Injury and Osteoarthritis Outcome Score (KOOS), six minute walk test (6MWT) and a validated MRI score were outcome measures.Results: There were significant improvements (p