The error threshold
The error threshold
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DOI：
10.1016/j.virusres.2004.11.002
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发表时间：
2005-02-01
期刊：
影响因子：
5
通讯作者：
Eigen, M
中科院分区：
文献类型：
--
作者：
Biebricher, CK;Eigen, M
介绍了细菌和病毒种群动态的基本原理，重点是 RNA 病毒。这里回顾的概念包括适应度、突变体生成、竞争、选择、序列空间和准种的理论起源。 “野生型”病毒不再被视为适者生存的类型，而是种群景观的重心。准种的结果是存在选择能力的错误阈值。误差阈值在准种理论中具有合理性，并且有助于探索驱动病毒种群超过误差阈值的策略，这是本书的中心主题。(C) 2004 Elsevier B.V. 保留所有权利。
Basic principles underlying the population dynamics of bacteria and viruses are presented, with emphasis on RNA viruses. Concepts reviewed here include fitness, mutant generation, competition, selection, sequence space and the theoretical origins of quasispecies. A "wild-type" virus is no longer viewed as the fittest type, but as the center of gravity of a population landscape. A consequence of quasispecies is the existence of an error threshold for selective competence. The error threshold has a justification in quasispecies theory and lends itself to exploration of strategies to drive viral populations over the error threshold, the central theme of this volume.(C) 2004 Elsevier B.V. All rights reserved.