CINCINNATA controls both cell differentiation and growth in petal lobes and leaves of antirrhinum
CINCINNATA controls both cell differentiation and growth in petal lobes and leaves of antirrhinum
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DOI：
10.1104/pp.103.036368
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发表时间：
2004-05-01
期刊：
影响因子：
7.4
通讯作者：
Coen, ES
中科院分区：
文献类型：
--
作者：
Crawford, BCW;Nath, U;Coen, ES
为了了解分化和生长在发育过程中是如何协调的，我们研究了金鱼草CINCINNATA（CIN）基因的作用。我们发现，除了影响叶片生长，CIN影响表皮细胞分化和花瓣裂片的生长。CIN的强等位基因使较小的花瓣叶具有平坦的而不是圆锥形的细胞，这与野生型中CIN的叶特异性表达相关。此外，叶缘的圆锥形细胞被扁平细胞所取代，表明CIN在叶和花瓣的细胞分化中起作用。弱半显性cin等位基因主要影响花瓣中的细胞类型，但不影响叶发育，表明这两种效应可以分开。CIN的表达与细胞分裂标志物的表达相关，表明CIN可能通过对细胞增殖的影响直接或间接地影响花瓣生长。对于叶和花瓣两者，CIN影响更远端和广泛延伸的结构域（叶片和花瓣裂片）的生长和分化。然而，虽然CIN促进花瓣的生长，但它促进叶片的生长停滞，这可能是因为这些系统中的生长控制模式不同。
To understand how differentiation and growth may be coordinated during development, we have studied the action of the CINCINNATA (CIN) gene of Antirrhinum. We show that in addition to affecting leaf lamina growth, CIN affects epidermal cell differentiation and growth of petal lobes. Strong alleles of cin give smaller petal lobes with flat instead of conical cells, correlating with lobe-specific expression of CIN in the wild type. Moreover, conical cells at the leaf margins are replaced by flatter cells, indicating that CIN has a role in cell differentiation of leaves as well as petals. A weak semidominant cin allele affects cell types mainly in the petal but does not affect leaf development, indicating these two effects can be separated. Expression of CIN correlates with expression of cell division markers, suggesting that CIN may influence petal growth, directly or indirectly, through effects on cell proliferation. For both leaves and petals, CIN affects growth and differentiation of the more distal and broadly extended domains (leaf lamina and petal lobe). However, while CIN promotes growth in petals, it promotes growth arrest in leaves, possibly because of different patterns of growth control in these systems.