The Role of DNA Methylation in Cardiovascular Risk and Disease: Methodological Aspects, Study Design, and Data Analysis for Epidemiological Studies.
The Role of DNA Methylation in Cardiovascular Risk and Disease: Methodological Aspects, Study Design, and Data Analysis for Epidemiological Studies.
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DOI：
10.1161/circresaha.115.305206
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发表时间：
2016-01-08
影响因子：
20.1
通讯作者：
Baccarelli AA
中科院分区：
文献类型：
--
作者：
Zhong J;Agha G;Baccarelli AA
流行病学研究表明，遗传、环境、行为和临床因素都对心血管疾病（CVD）的发展有影响。这些风险因素在细胞水平上如何相互作用导致心血管疾病尚不明确。表观遗传流行病学使研究人员能够探索基因组编码、可改变的暴露因素和疾病表型表现之间的关键联系。一种表观遗传联系，即DNA甲基化，可能是这些关联背后的一个重要机制。在过去十年中，调查与DNA甲基化相关的心血管风险因素和结果的流行病学研究数量显著增加，但我们对潜在病因和生物学意义的理解仍存在许多空白。在这篇综述中，我们简要概述了DNA甲基化的生物学和机制及其在心血管疾病中的作用。此外，我们总结了与心血管健康和疾病相关的表观遗传流行病学研究的当前证据基础，并讨论了该领域的局限性、挑战和未来方向。最后，我们为精心设计的表观遗传流行病学研究提供了指南，特别关注方法学方面、研究设计和分析挑战。
Epidemiological studies have demonstrated that genetic, environmental, behavioral, and clinical factors contribute to cardiovascular disease (CVD) development. How these risk factors interact at the cellular level to cause CVD is not well known. Epigenetic epidemiology enables researchers to explore critical links between genomic coding, modifiable exposures, and manifestation of disease phenotype. One epigenetic link, DNA methylation, is potentially an important mechanism underlying these associations. In the past decade, there has been a significant increase in the number of epidemiological studies investigating cardiovascular risk factors and outcomes in relation to DNA methylation, but many gaps remain in our understanding of the underlying etiology and biological implications. In this review we provide a brief overview of the biology and mechanisms of DNA methylation and its role in CVD. In addition, we summarize the current evidence base in epigenetic epidemiology studies relevant to cardiovascular health and disease, and discuss the limitations, challenges, and future directions of the field. Finally, we provide guidelines for well-designed epigenetic epidemiology studies, with particular focus on methodological aspects, study design, and analytical challenges.
影响因子：
3.7
作者：
Lowe R;Morris T
通讯作者：
Morris T