An AC magnetohydrodynamic microfluidic switch for micro total analysis systems
An AC magnetohydrodynamic microfluidic switch for micro total analysis systems
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DOI：
10.1023/a:1024415400633
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发表时间：
2003-03-01
影响因子：
2.8
通讯作者：
Lee, AP
中科院分区：
文献类型：
--
作者：
Lemoff, AV;Lee, AP
本文报道了一种磁流体动力学（MHD）微流控开关，它可以构成一般微流控电路的基础。该开关使用交流MHD泵送机构，其中洛伦兹力用于泵送电解溶液。通过将两个交流MHD泵集成到y形流体回路的不同臂中，通过激活其中一个微泵并将另一个微泵设置为抵消压力以阻止流动，可以在两个臂之间切换流量。水流可以以0.3毫米/秒的速度从一个微通道切换到另一个微通道。这种类型的开关很容易与其他生物芯片集成，可用于产生复杂的流体路由，这可能在微全分析系统（muTAS）中有多种应用。应用实例包括用于药物发现和药物测试的片上组合化学，用于将样品路由到不同检测器的连接器，以及一般可重构分析。
In this paper, a magnetohydrodynamic (MHD) microfluidic switch, which could form the basis for general microfluidic circuits, is reported. The switch uses an AC MHD pumping mechanism in which the Lorentz force is used to pump electrolytic solutions. By integrating two AC MHD pumps into different arms of a Y-shaped fluidic circuit, flow can be switched between the two arms by activating one of the micropumps and setting the other one at a counteracting pressure to prevent flow. Flow could be switched from one microchannel to another at a velocity of 0.3 mm/sec. This type of switch is easily integrated with other biochips and can be used to produce complex fluidic routing, which may have multiple applications in micro total analysis systems (muTAS). Examples of applications include on-chip combinatorial chemistry for drug discovery and drug testing, connectors for routing samples to different detectors, and general reconfigurable assays.