New views on endothelial dysfunction in gestational hypertension and potential therapy targets.
New views on endothelial dysfunction in gestational hypertension and potential therapy targets.
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DOI：
10.1016/j.drudis.2021.03.001
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发表时间：
2021-03
影响因子：
7.4
通讯作者：
Xueqin Feng;Yanping Liu;Yingying Zhang;Yumeng Zhang;Huan Li;Qiutong Zheng;Na Li;Jiaqi Tang-
中科院分区：
文献类型：
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作者：
Xueqin Feng;Yanping Liu;Yingying Zhang;Yumeng Zhang;Huan Li;Qiutong Zheng;Na Li;Jiaqi Tang-
重点回顾了妊娠高血压的主要理论，着重阐述了内皮细胞功能障碍，即内皮细胞NO功能弱，外源性NO使胎盘血管张力曲线出现“大凹陷”，对胎盘内皮功能障碍与妊娠高血压的关系提出了新的看法。胎盘在代谢物交换、胎儿生长发育和先兆子痫（PE）中起着重要作用。本文就妊娠期高血压的发病机制作一综述，重点介绍了妊娠期高血压的四种主要理论，并讨论了内皮细胞在这些理论中的作用。本文着重研究了一氧化氮（NO）和前列环素（PGI2）在胎盘内皮细胞中的作用，并对内皮细胞NO和PGI2信号通路在PE中的作用和机制提出了新的假说。
HighlightsReviewing major theories on pregnant hypertension & focusing on endothelial dysfunction.Endothelial NO is weak & exogenous NO makes “big dent” on placental vessel tension curve.New views on placental endothelial dysfunction contributing to pregnant hypertension.The placenta has vital roles in metabolite exchange, fetal growth, and pre-eclampsia (PE). In this review, we discuss the pathogenesis of hypertension in pregnancy, focusing on four major theories to explain PE, discussing endothelial roles in those theories. We focus in particular on the roles of nitric oxide (NO) and prostacyclin (PGI 2) in placental endothelium, and propose new hypotheses for the influence and mechanisms of endothelial NO and PGI 2 signaling pathways in PE.