The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling
The receptor kinase FER is a RALF-regulated scaffold controlling plant immune signaling
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DOI：
10.1126/science.aal2541
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发表时间：
2017-01-20
期刊：
影响因子：
56.9
通讯作者：
Zipfel, Cyril
中科院分区：
文献类型：
--
作者：
Stegmann, Martin;Monaghan, Jacqueline;Zipfel, Cyril
在植物中，入侵病原体的感知涉及细胞表面免疫受体激酶。在这里，我们报告，拟南芥SITE-1蛋白酶（S1 P）切割内源性快速碱化因子（RALF）前肽抑制植物免疫。这种抑制作用由马来凝集素样受体激酶FERONIA（FER）介导，其促进免疫受体激酶EF-TU受体（EFR）和鞭毛蛋白敏感2（FLS 2）与其共受体油菜甾醇不敏感1相关激酶1（BAK 1）的配体诱导复合物形成，以启动免疫信号传导。我们表明，FER作为一个RALF调节的支架，调节受体激酶复合物的组装。类似的支架机制可能是FER在其他信号通路中的功能的基础。
In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling. We show that FER acts as a RALF-regulated scaffold that modulates receptor kinase complex assembly. A similar scaffolding mechanism may underlie FER function in other signaling pathways.