TRUNCATED GLP-1 (PROGLUCAGON 78-107-AMIDE) INHIBITS GASTRIC AND PANCREATIC FUNCTIONS IN MAN
TRUNCATED GLP-1 (PROGLUCAGON 78-107-AMIDE) INHIBITS GASTRIC AND PANCREATIC FUNCTIONS IN MAN
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DOI：
10.1007/bf01316798
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发表时间：
1993-04-01
影响因子：
3.1
通讯作者：
HOLST, JJ
中科院分区：
文献类型：
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作者：
WETTERGREN, A;SCHJOLDAGER, B;HOLST, JJ
我们研究了静脉输注合成的截短型GLP-1（胰高血糖素原78-107-酰胺）对8名正常志愿者空腹和餐后胃酸分泌、胃排空以及胰蛋白酶和脂肪酶分泌的影响。输注导致血浆浓度为110 +/- 14 pmol/L（平均值+/- SEM）。截短的GLP-1显著抑制餐后酸分泌43 +/- 11%，尽管血浆胃泌素浓度不变。胃排空率显著降低; 50%排空时间从16 +/- 2 min延长至30 +/- 5 min。在截短GLP-1输注期间，餐后胰蛋白酶和脂肪酶输出分别受到47 +/-17%和40 +/- 9%的显著抑制。胰酶输出与胃排空呈线性相关，截短的GLP-1不影响这种关系，表明对胰腺分泌的影响仅次于对胃排空的影响。尽管血糖水平显著降低（5.2 +/- 0.2 vs 3.7 +/- 0.3），但在有和无截短GLP-1输注的情况下，餐后胰岛素和胰高血糖素浓度相似，表明GLP-1刺激胰岛素分泌并抑制胰高血糖素分泌。总之，我们的研究结果表明，截短GLP-1作为一种生理抑制剂的胃和胰腺功能的人。
We studied the effect of intravenous infusion of synthetic truncated GLP-1 (proglucagon 78-107-amide) on fasting and postprandial gastric acid secretion, gastric emptying, and pancreatic secretion of trypsin and lipase in eight normal volunteers using marker dilution and aspiration technique. The infusion resulted in a plasma concentration of 110 +/- 14 pmol/liter (mean +/- SEM). Truncated GLP-1 significantly inhibited postprandial acid secretion by 43 +/- 11% in spite of unchanged plasma gastrin concentration. Gastric emptying rate decreased significantly; 50% emptying time increased from 16 +/- 2 min to 30 +/- 5 min. Postprandial trypsin and lipase outputs were significantly inhibited by 47 +/-17% and 40 +/- 9% during truncated GLP-1 infusion. Pancreatic enzyme output was linearly correlated to gastric emptying, and truncated GLP-1 did not affect this relationship, suggesting that the effect on pancreatic secretion was secondary to the effect on gastric emptying. Postprandial insulin and glucagon concentrations were similar with and without truncated GLP-1 infusion in spite of significantly lower blood glucose levels (5.2 +/- 0.2 versus 3.7 +/- 0.3), indicating that GLP-1 stimulated insulin secretion and inhibited glucagon secretion. In conclusion, our results suggest that truncated GLP-1 act as a physiological inhibitor of gastric and pancreatic functions in man.