Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids
Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids
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DOI：
10.1093/jn/130.11.2733
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发表时间：
2000-11-01
影响因子：
4.2
通讯作者：
Scalbert, A
中科院分区：
文献类型：
--
作者：
Déprez, S;Brezillon, C;Scalbert, A
聚合原花青素是许多食品和饮料的常见成分。它们在人体内的命运在很大程度上仍然未知。他们的代谢培养在体外缺氧条件下的人结肠微生物已被调查使用非标记和C-14标记的纯化原花青素聚合物。培养48小时后，聚合物几乎完全降解。通过气相色谱-质谱联用（GC-MS）将主要在Meta位或pam位单羟基化的苯乙酸、苯丙酸和苯戊酸鉴别为代谢物。产率与先前报道的黄酮类单体相似。这些结果提供了膳食酚聚合物降解成低分子量芳香族化合物的第一个证据。为了了解原花青素的营养特性，因此必须考虑这些代谢产物的生物学特性。
Polymeric proanthocyanidins are common constituents of many foods and beverages. Their fate in the human body remains largely unknown. Their metabolism by human colonic microflora incubated in vitro in anoxic conditions has been investigated using nonlabeled and C-14-labeled purified proanthocyanidin polymers. Polymers were almost totally degraded after 48 h of incubation. Phenylacetic, phenylpropionic and phenylvaleric acids, monohydroxylated mainly in the meta or pam position, were identified as metabolites by gas chromatography coupled to mass spectrometry (GC-MS). Yields were similar to those previously reported for flavonoid monomers. These results provide the first evidence of degradation of dietary phenolic polymers into low-molecular-weight aromatic compounds. To understand the nutritional properties of proanthocyanidins, it is therefore essential to consider the biological properties of these metabolites.