Risk of amyotrophic lateral sclerosis and history of physical activity - A population-based case-control study
Risk of amyotrophic lateral sclerosis and history of physical activity - A population-based case-control study
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DOI：
10.1001/archneur.55.2.201
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发表时间：
1998-02-01
影响因子：
--
通讯作者：
van Belle, G
中科院分区：
文献类型：
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作者：
Longstreth, WT;McGuire, V;van Belle, G
目的：为了更详细地评估比以前的研究声称的体育活动史和肌萎缩侧索硬化症（ALS）之间的关联：一个以人群为基础的病例对照研究，以确定ALS的危险因素。病例患者来自华盛顿州西部的3个县，由神经科医生新诊断为ALS。通过随机数字电话拨号或从医疗保险资格名单中随机选择与每个病例患者在5年内性别和年龄相匹配的两名对照受试者。所有受试者都进行了面对面的结构化访谈，包括参考日期之前有关身体活动的详细信息，参考日期是病例患者被诊断为ALS的月份和年份。在工作和休闲时间的体力活动的各种措施进行了评估，使用条件Logistic回归考虑到性别和年龄的匹配。结果：一百七十四例患者和348名对照组参加了这项研究。无论是在工作，休闲时间或两者结合，无论是在一个人的一生中（从10年前的参考日期回到15岁）或在特定的几十年前参考日期的体力活动是没有显着差异的情况下，患者和对照组。一个例外的情况下，患者报告参加有组织的体育活动，在高中比对照组（比值比，1.52; 95%置信区间，1.03-2.25）。结论：体育活动的历史几乎没有，如果有的话，对ALS的风险的影响。
Objective: To assess in greater detail than previous studies the purported association between a history of physical activity and amyotrophic lateral sclerosis (ALS).Methods: A population-based case-control study was used to identify risk factors for ALS. Case patients were from 3 counties of western Washington State who were newly diagnosed as having ALS by a neurologist. Two control subjects matched with each case patient for sex and age within 5 years were identified by random digit telephone dialing or random selection from Medicare eligibility lists. All subjects underwent an in-person structured interview including detailed information about physical activity before a reference date, which was the month and year the case patient was diagnosed as having ALS. Various measures of physical activity both at work and leisure time were evaluated using conditional logistic regression taking into account the matching for sex and age.Results: One hundred seventy-four case patients and 348 control subjects participated in the study. Physical activity was not significantly different between case patients and controls-whether at work, leisure time or both combined, and whether during a person's lifetime (from 10 years before reference date back to age 15 years) or during specific decades before reference date. An exception was that case patients reported having participated in organized sports in high school slightly more frequently than control subjects (odds ratio, 1.52; 95% confidence interval, 1.03-2.25).Conclusion: A history of physical activity has little, if any, effect on the risk of ALS.