Acquisition, extinction, and recall of opiate reward memory are signaled by dynamic neuronal activity patterns in the prefrontal cortex.
Acquisition, extinction, and recall of opiate reward memory are signaled by dynamic neuronal activity patterns in the prefrontal cortex.
复制标题
DOI：
10.1093/cercor/bhr031
复制
发表时间：
2011-12
期刊：
影响因子：
3.7
通讯作者：
Ninglei Sun;Ning Chi;Nicole M. Lauzon;Stephanie F. Bishop;Huibing Tan;S. Laviolette
中科院分区：
文献类型：
--
作者：
Ninglei Sun;Ning Chi;Nicole M. Lauzon;Stephanie F. Bishop;Huibing Tan;S. Laviolette
内侧前额叶皮层（mPFC）是药物相关的联想学习和记忆处理的神经回路的重要组成部分。在人类和其他动物中，mPFC回路内的神经元激活与阿片类药物相关的吸毒经历的回忆相关。使用无偏的关联位置条件反射程序，我们记录了mPFC神经元群体在收购，回忆和灭绝阶段的吗啡相关的联想学习和记忆。我们的分析表明，mPFC神经元表现出增加的活动，无论是在收购阶段的阿片奖励相关的记忆和表现出刺激锁定的关联活动的变化，在真实的时间，在阿片奖励记忆的回忆，在紧张和阶段性的活动模式。有趣的是，mPFC神经元群体表现出不同的模式的突发活动在收购与回忆阶段的新收购的阿片奖励记忆，与这些记忆的灭绝，强烈增加突发在回忆的灭绝记忆和没有关联的突发在回忆的新收购的阿片奖励记忆。我们的研究结果表明，mPFC内的神经元参与了阿片类药物相关的奖励记忆的获取，回忆和消退，在阿片类药物相关的奖励学习和记忆回忆的这些单独的组成部分中显示出独特的强直和阶段性活动模式。
The medial prefrontal cortex (mPFC) comprises an important component in the neural circuitry underlying drug-related associative learning and memory processing. Neuronal activation within mPFC circuits is correlated with the recall of opiate-related drug-taking experiences in both humans and other animals. Using an unbiased associative place conditioning procedure, we recorded mPFC neuronal populations during the acquisition, recall, and extinction phases of morphine-related associative learning and memory. Our analyses revealed that mPFC neurons show increased activity both in terms of tonic and phasic activity patterns during the acquisition phase of opiate reward-related memory and demonstrate stimulus-locked associative activity changes in real time, during the recall of opiate reward memories. Interestingly, mPFC neuronal populations demonstrated divergent patterns of bursting activity during the acquisition versus recall phases of newly acquired opiate reward memory, versus the extinction of these memories, with strongly increased bursting during the recall of an extinction memory and no associative bursting during the recall of a newly acquired opiate reward memory. Our results demonstrate that neurons within the mPFC are involved in both the acquisition, recall, and extinction of opiate-related reward memories, showing unique patterns of tonic and phasic activity patterns during these separate components of the opiate-related reward learning and memory recall.