Long-term effect of low-frequency repetitive transcranial magnetic stimulation over the unaffected posterior parietal cortex in patients with unilateral spatial neglect
Long-term effect of low-frequency repetitive transcranial magnetic stimulation over the unaffected posterior parietal cortex in patients with unilateral spatial neglect
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DOI：
10.1080/16501970500441807
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发表时间：
2006-01-01
影响因子：
3.5
通讯作者：
Izumi, SI
中科院分区：
文献类型：
--
作者：
Shindo, K;Sugiyama, K;Izumi, SI
目的：探讨低频重复经颅磁刺激（rTMS）对未受影响的后顶叶皮层单侧空间忽视的长期影响。设计：非对照试验研究。研究对象：脑梗死后左侧单侧空间忽视慢性期患者2例。方法：进行6次rTMS治疗，疗程2周。每组包括900个刺激，频率为0.9 Hz，强度为95%的运动阈值。行为注意力不集中测试、迷你精神状态检查或修订的长谷川痴呆量表、Brunnstrom恢复阶段和Barthel指数在rTMS后每隔2周进行一次评估，直到6周。分别于rTMS前后2周进行单光子发射计算机断层扫描。结果：行为注意力不集中测试成绩显著提高，特别是在rTMS治疗后2至4周。在6周时，行为注意力不集中测试分数仍然高于rtms前的水平。其他临床评估以及单光子发射计算机断层扫描显示在研究期间无显著变化。结论：在这个小规模的初步研究中，低频rTMS在未受影响的后顶叶皮层上减少了至少6周的单侧空间忽视。
Objective: To explore long-term effects on unilateral spatial neglect of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the unaffected posterior parietal cortex.Design: Uncontrolled pilot study.Subjects: Two chronic-phase patients with left-sided unilateral spatial neglect from cerebral infarction.Methods: Six rTMS sessions were undertaken for 2 weeks. Each session included 900 stimuli applied over P5 at an intensity of 95% motor thresholds and a frequency of 0.9 Hz. The Behavioural Inattention Test, either the Mini-Mental State Examination or the Revised Hasegawa Dementia Scale, Brunnstrom Recovery Stage, and Barthel Index were evaluated at 2-week intervals until 6 weeks after rTMS sessions. Single-photon emission computed tomography was performed 2 weeks before and after rTMS.Results: Behavioural Inattention Test scores improved remarkably, especially from 2 to 4 weeks after rTMS sessions. At 6 weeks, Behavioural Inattention Test scores still remained above pre-rTMS levels. Other clinical evaluations as well as single-photon emission computed tomography showed no significant change during the study.Conclusion: In this small pilot study, low-frequency rTMS over the unaffected posterior parietal cortex decreased unilateral spatial neglect for at least 6 weeks.