Broad oxygen tolerance in the nematode Caenorhabditis elegans.
Broad oxygen tolerance in the nematode Caenorhabditis elegans.
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发表时间：
2000-08
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通讯作者：
W. Voorhies;S. Ward
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作者：
W. Voorhies;S. Ward
研究了0 ~ 90 kPa的氧张力对自由生活的秀丽隐杆线虫的代谢率、运动和存活率的影响。C.线虫需要氧气来发育和生存。然而，它可以在3.6 kPa的氧气水平下保持正常的代谢率，并且在低至2 kPa的氧气水平下具有接近正常的代谢率。能够承受低的环境氧气水平似乎是一个小的身体大小的C的结果。elegans，它允许扩散以容易地向细胞供应氧气，而不需要任何专门的呼吸或代谢适应。因此，这种生物体的小尺寸预先适应C。生活在通常变得缺氧的土壤环境中。运动在C。秀丽线虫似乎具有相对较小的代谢成本。C.秀丽线虫能够耐受长达24小时的缺氧而没有大的死亡率。较长时间的缺氧显著增加死亡率，特别是对鸡蛋。值得注意的是，长期暴露在100%的氧气中对C的代谢率没有影响。并且种群能够在100%（90 kPa）氧气中存活至少50代。这种高氧条件在短时间内对大多数生物是致命的。
This study examined the effects of oxygen tensions ranging from 0 to 90 kPa on the metabolic rate (rate of carbon dioxide production), movement and survivorship of the free-living soil nematode Caenorhabditis elegans. C. elegans requires oxygen to develop and survive. However, it can maintain a normal metabolic rate at oxygen levels of 3.6 kPa and has near-normal metabolic rates at oxygen levels as low as 2 kPa. The ability to withstand low ambient oxygen levels appears to be a consequence of the small body size of C. elegans, which allows diffusion to supply oxygen readily to the cells without requiring any specialized respiratory or metabolic adaptations. Thus, the small size of this organism pre-adapts C. elegans to living in soil environments that commonly become hypoxic. Movement in C. elegans appears to have a relatively minor metabolic cost. Several developmental stages of C. elegans were able to withstand up to 24 h of anoxia without major mortality. Longer periods of anoxia significantly increased mortality, particularly for eggs. Remarkably, long-term exposure to 100 % oxygen had no effect on the metabolic rate of C. elegans, and populations were able to survive for a least 50 generations in 100 % (90 kPa) oxygen. Such hyperoxic conditions are fatal to most organisms within a short period.