Id family of helix-loop-helix proteins in cancer
Id family of helix-loop-helix proteins in cancer
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DOI：
10.1038/nrc1712
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发表时间：
2005-09
影响因子：
78.5
通讯作者：
Jonathan Perk;A. Iavarone;R. Benezra
中科院分区：
文献类型：
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作者：
Jonathan Perk;A. Iavarone;R. Benezra
在过去的几十年里，生物学家已经确定了与各种人类癌症相关的关键分子特征。最近，动物模型已特别有用，在建立这样的签名是否具有功能相关性;过度表达的致癌或抗癌因子的损失已被评估其对各种肿瘤模型的影响。本综述的目的是分析DNA结合（Id）蛋白抑制剂在癌症中的潜在作用，并检查Id活性是否失调是致瘤性的，并有助于恶性肿瘤的标志，如分化丧失（间变性），不受限制的增殖和新血管生成。
Over the past few decades, biologists have identified key molecular signatures associated with a wide range of human cancers. Recently, animal models have been particularly useful in establishing whether such signatures have functional relevance; the overexpression of pro-oncogenic or loss of anti-oncogenic factors have been evaluated for their effects on various tumour models. The aim of this review is to analyze the potential role of the inhibitor of DNA binding (Id) proteins in cancer and examine whether deregulated Id activity is tumorigenic and contributes to hallmarks of malignancy, such as loss of differentiation (anaplasia), unrestricted proliferation and neoangiogenesis.