High-energy 595 nm pulsed dye laser improves refractory port-wine stains
High-energy 595 nm pulsed dye laser improves refractory port-wine stains
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DOI：
10.1097/00042728-200601000-00005
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Bernstein, EF
中科院分区：
文献类型：
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作者：
Bernstein, EF
葡萄酒色斑对585 nm脉冲染料激光治疗反应良好，但通常不能完全清除。我们研究了一个原型，一个高能量的595 nm脉冲染料激光器，能够提供高达9.5 J/cm（2），使用10 mm的圆形光斑，与1.5 ms的脉冲宽度。可变脉宽脉冲染料激光器可以改善端口，葡萄酒污渍已成为传统治疗难治性。方法20例患者进入研究，并与高能量，595 rim，可变脉冲持续时间脉冲染料激光器，使用范围从75至9.5J/cm（2）的注量，1.5ms脉冲持续时间，结果在研究开始前，在平均能量为7.9 J/cm（2）的条件下，平均治疗8.8次后，平均改善率为40%使用585 nm脉冲染料激光治疗，平均3.1次高能595 nm脉冲染料激光治疗后，平均通量为7.9 J/cm（2），皮肤光谱仪红斑测量从正常皮肤的2.2倍提高到1.5倍，未受影响的skin.CONCLUSIONS高能量595 nm脉冲染料激光改善波特酒污渍，已成为难治性的传统585 nm脉冲染料激光。
BACKGROUND Port-wine stains respond quite well to 585 nm pulsed dye laser treatment, but often clearance is not complete. We investigated a prototype, a high-energy 595 nm pulsed dye laser capable of delivering Up to 9.5 J/cm(2) using a 10 mm circular spot, with a 1.5 ms pulse duration.OBJECTIVE This study was undertaken to determine if the high-energy, 595 nm, variable-pulse duration pulsed dye laser could improve port-wine stains that had become refractory to conventional treatment.METHODS Twenty patients were entered into the study and treated with the high-energy, 595 rim, variable-pulse duration pulsed dye laser using fluences ranging from 75 to 9.5 J/cm(2), a 1.5 ms pulse duration, and a 10 mm spot size.RESULTS Average improvement was rated as 40% prior to the initiation of the study after an average of 8.8 treatments at an average energy of 7.9 J/cm(2) with the 585 nm pulsed dye laser and 76% following an average of 3.1 treatments with the high-energy 595 nm pulsed dye laser using an average fluence of 7.9 J/cm(2). Dermal spectrometer erythema measurements improved from 2.2-fold that of normal skin to 1.5-fold that of unaffected skin.CONCLUSIONS The high-energy 595 nm pulsed dye laser improves port-wine stains that have become refractory to the conventional 585 nm pulsed dye laser.