Alginate Film as a Novel Post-Surgical Tissue Adhesion Barrier
Alginate Film as a Novel Post-Surgical Tissue Adhesion Barrier
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DOI：
10.1163/156856209x435835
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发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Lee, Jin Ho
中科院分区：
文献类型：
--
作者：
Cho, Wan Jin;Oh, Se Heang;Lee, Jin Ho
在本研究中，我们重点研究了藻酸盐作为一种物理组织黏附屏障材料。海藻酸盐在固体状态下具有粘附性，在溶解状态下形成粘滑的凝胶状溶液。我们推测，没有交联物的海藻酸盐膜可能是一种很好的组织黏附屏障。由于其粘附性，非交联型海藻酸盐膜可以稳定地附着在伤口上，因此不需要缝合来固定伤口，然后当与体液接触时，该膜可以通过水合慢慢变成滑凝胶，从而有效地将伤口与周围组织分开而不粘连。为了验证我们的假设，我们制备了一种非交联型海藻酸膜，通过与不同类型的海藻酸盐(粘性溶液、凝胶以及交联膜)和商业化的组织粘连屏障Interceed(TM)的比较，通过对大鼠手术后腹膜粘连的研究，评估了其作为组织粘连屏障的潜力。从动物研究中观察到，未交联藻酸膜在预防腹膜组织粘连方面比其他类型的藻酸盐更有效，包括商品化的藻酸盐，这可能是由于其独特的粘附性(提供驻留稳定性而无需缝合在损伤部位)和在伤口愈合期间的润滑性(通过与体液接触水合)。未交联的海藻酸盐膜在伤口愈合过程中也表现出低的炎症反应，并且不会导致特定的组织学影响。由此可见，未交联的海藻酸盐膜有望成为一种简单有效的组织黏附屏障，适用于各种损伤组织。(C)Koninklijke Brill NV，莱顿，2010
In this study, we focused on alginate as a physical tissue adhesion barrier material. The alginate has a muco-adhesive property in the solid state and becomes a viscous slippery gel-like solution in the dissolved state. We hypothesized that the alginate film without cross-linking can be a good candidate as a tissue adhesion barrier. The un-cross-linked alginate film may stably adhere onto a wound owing to its muco-adhesive property and, thus, does not need suturing to fix it, and then the film may slowly change into a slippery gel by hydration when in contact with body fluid and, thus, effectively separate the wound from the surrounding tissue without adhesion. To verify our hypothesis, we fabricated a un-cross-linked alginate film and its potential as a tissue adhesion barrier was evaluated through the comparison with various types of alginate (viscous solution and gel as well as cross-linked film) and a commercialized tissue adhesion barrier, Interceed (TM), by the investigation of post-surgical peritoneal adhesion using a rat model. From the animal study, it was observed that the un-cross-linked alginate film was more effective for the prevention of peritoneal tissue adhesion than other types of alginates, including the commercialized one, probably owing to its unique muco-adhesive property (providing residence stability without suturing at the injured site) and lubricant property (by hydration in contact with body fluid) during wound healing. The un-cross-linked alginate film also showed a low inflammatory response and did not lead to specific histological influence during the wound healing. From these observations, the un-cross-linked alginate film is expected to be a simple and efficient tissue adhesion barrier applicable to various injury tissues. (C) Koninklijke Brill NV, Leiden, 2010