Aging of cerebellar Purkinje cells
Aging of cerebellar Purkinje cells
复制标题
小脑浦肯野细胞的衰老
DOI：
10.1007/s00441-010-1016-2
复制
发表时间：
2010
影响因子：
3.6
通讯作者：
T. Hua
中科院分区：
文献类型：
--
作者：
Changzheng Zhang;Q. Zhu;T. Hua
小脑浦肯野细胞是小脑皮层唯一的输出神经元，在小脑回路中起着重要的作用。pc对衰老相当敏感，在衰老过程中表现出明显的形态和功能变化。本文综述了正常衰老过程中的这些变化，包括细胞数量的减少、体细胞的萎缩、树突的收缩、亚细胞器的退化、突触密度的下降、神经递质系统的紊乱以及电生理特性的改变。尽管这些退化变化发生在衰老过程中，但存在代偿机制来抵消老化的pc中的损伤。讨论了这些变化的可能神经机制和潜在的预防治疗方法。
Cerebellar Purkinje cells (PCs), the sole output neurons in the cerebellar cortex, play an important role in the cerebellar circuit. PCs appear to be rather sensitive to aging, exhibiting significant changes in both morphology and function during senescence. This article reviews such changes during the normal aging process, including a decrease in the quantity of cells, atrophy in the soma, retraction in the dendritic arborizations, degeneration in the subcellular organelles, a decline in synapse density, disorder in the neurotransmitter system, and alterations in electrophysiological properties. Although these deteriorative changes occur during aging, compensatory mechanisms exist to counteract the impairments in the aging PCs. The possible neural mechanisms underlying these changes and potential preventive treatments are discussed.