Adenovirus type 11 binding alters the conformation of its receptor CD46
Adenovirus type 11 binding alters the conformation of its receptor CD46
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DOI：
10.1038/nsmb1190
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发表时间：
2007-02-01
影响因子：
16.8
通讯作者：
Stehle, Thilo
中科院分区：
文献类型：
--
作者：
Persson, B. David;Reiter, Dirk M.;Stehle, Thilo
腺病毒（AdenovirusAds）是重要的人类病原体和基因载体。在这里，我们报告的晶体结构的物种B Ad11球与其受体CD46的Ad11结合区复合。结合CD46的构象与其未结合状态有很大不同，弯曲的表面结构伸直成细长的杆。这种相互作用机制可能在靶向CD46或相关分子的许多病原体中是保守的。
Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.