CHARACTERISTICS OF VIRULENT, ATTENUATED, AND AVIRULENT MYCOPLASMA PNEUMONIAE STRAINS
CHARACTERISTICS OF VIRULENT, ATTENUATED, AND AVIRULENT MYCOPLASMA PNEUMONIAE STRAINS
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DOI：
10.1128/jb.100.2.1037-1043.1969
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发表时间：
1969-01-01
影响因子：
3.2
通讯作者：
DENNY, FW
中科院分区：
文献类型：
--
作者：
LIPMAN, RP;CLYDE, WA;DENNY, FW
衍生并比较了强毒力和减毒力或无毒力肺炎支原体菌株的同源对，以努力阐明毒力机制。发现这些相关菌株在生长、糖酵解、蛋白质电泳模式、过氧化物形成、形态和细胞吸附方面存在差异。最后两个特征的变化与无毒力密切相关。这使得能够了解致病序列的一个阶段，并为无毒力提供方便的标记。传染性无毒株的衍生可能使它们能够用作针对支原体的活疫苗。肺炎疾病。
Homologous pairs of virulent and attenuated or avirulentMycoplasma pneumoniaestrains were derived and compared in an effort to elucidate the mechanisms of virulence. These related strains were found to vary in growth, glycolysis, protein electrophoretic patterns, peroxide formation, morphology, and cytadsorption. Variations in the last two characteristics closely correlated with avirulence. This enables understanding of one stage in the pathogenic sequence and provides a convenient marker for avirulence. The derivation of infectious avirulent strains may make possible their use as live vaccines againstM. pneumoniaedisease.