In vivo drug tracking with 19F MRI at therapeutic dose
In vivo drug tracking with 19F MRI at therapeutic dose
复制标题
使用 19F MRI 在治疗剂量下进行体内药物追踪
DOI：
10.1039/c7cc09898g
复制
发表时间：
2018-04-17
影响因子：
4.9
通讯作者：
Jiang, Zhong-Xing
中科院分区：
文献类型：
--
作者：
Bo, Shaowei;Yuan, Yaping;Jiang, Zhong-Xing
利用F-19 MRI跟踪药物将有利于开发治疗诊断学和优化药物治疗。为此，已经开发了具有高F-19 MRI灵敏度和生物相容性的氟化树枝状两亲物，用于小鼠中的阿霉素（DOX）负载脂质体的F-19 MRI追踪，这可能提供用F-19 MRI在体内追踪各种药物的有效平台。
Tracking drugs with F-19 MRI would be beneficial for developing theranostics and optimizing drug therapy. To this end, a fluorinated dendritic amphiphile with high F-19 MRI sensitivity and biocompatibility has been developed for F-19 MRI tracking of doxorubicin (DOX)-loaded liposomes in mice, which may provide an effective platform to in vivo trace various drugs with F-19 MRI.