Using markers in gene introgression breeding programs.
Using markers in gene introgression breeding programs.
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DOI：
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发表时间：
1992-12
期刊：
影响因子：
3.3
通讯作者：
F. Hospital;C. Chevalet;P. Mulsant
中科院分区：
文献类型：
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作者：
F. Hospital;C. Chevalet;P. Mulsant
我们调查使用标记，以加快恢复的受体基因组在渐渗育种计划。研究了选择时间和强度、群体大小、选择标记的数量和位置对携带或不携带渐渗基因的染色体的影响。我们表明，标记辅助选择可能会导致增益的时间约两代，效率低于以前的理论预测。标记在其地图位置已知时最有用。在早期世代中，表明每个非携带者染色体上增加超过三个标记的数量是无效的，渗入基因周围的区段由相当远的标记更好地控制，除非可以应用高选择强度，并且首先在该区段上选择可以降低可用于在非携带者染色体上选择的选择强度。这些结果用于提出全基因组选择的最佳策略，充分利用可用的材料和条件（例如，人口规模和生育率，遗传图谱）。
We investigate the use of markers to hasten the recovery of the recipient genome during an introgression breeding program. The effects of time and intensity of selection, population size, number and position of selected markers are studied for chromosomes either carrying or not carrying the introgressed gene. We show that marker assisted selection may lead to a gain in time of about two generations, an efficiency below previous theoretical predictions. Markers are most useful when their map position is known. In the early generations, it is shown that increasing the number of markers over three per non-carrier chromosome is not efficient, that the segment surrounding the introgressed gene is better controlled by rather distant markers unless high selection intensity can be applied, and that selection on this segment first can reduce the selection intensity available for selection on non-carrier chromosomes. These results are used to propose an optimal strategy for selection on the whole genome, making the most of available material and conditions (e.g., population size and fertility, genetic map).