Tris(pentafluorophenyl)borane-Catalyzed Stereospecific Bromocyanation of Styrene Derivatives with Cyanogen Bromide
Tris(pentafluorophenyl)borane-Catalyzed Stereospecific Bromocyanation of Styrene Derivatives with Cyanogen Bromide
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DOI：
10.1021/acs.orglett.3c00727
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发表时间：
2023-03-27
期刊：
影响因子：
5.2
通讯作者：
Minakata，Satoshi
中科院分区：
文献类型：
--
作者：
Kiyokawa，Kensuke;Noguchi，Ikumi;Minakata，Satoshi
本文报道了苯乙烯衍生物与溴化氰在三（五氟苯基）硼烷存在下的溴氰化反应。三（五氟苯基）硼烷作为一种刘易斯酸催化剂，能有效地活化溴化氰。该反应通过立体特异性合成加成进行。该议定书操作简单，并提供了实际的β-溴腈。
We, herein, report on the bromocyanation of styrene derivatives with cyanogen bromide in the presence of tris(pentafluorophenyl)borane which functions as a Lewis acid catalyst that can effectively activate cyanogen bromide. This reaction proceeds through a stereospecificsyn-addition. The protocol is operationally simple and provides practical access to β-bromonitriles.