Taste perception of cyclic oligosaccharides: α, β, and γ cyclodextrins.
Taste perception of cyclic oligosaccharides: α, β, and γ cyclodextrins.
复制标题
环状寡糖的味觉：α、β和γ环糊精。
DOI：
10.1093/chemse/bjac006
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发表时间：
2022
期刊：
影响因子：
3.5
通讯作者：
Lim,Juyun
中科院分区：
文献类型：
--
作者：
Martin,LauraE;Lim,Juyun
低聚糖是复杂碳水化合物的一个子类，天然存在于食物中，也是口服淀粉消化的结果。我们之前已经证明，人类可以品尝麦芽低聚糖（MOS），并且它们的检测独立于典型的甜味受体。虽然 MOS 最常以线性形式存在，但它们也可以以环状结构存在，称为环糊精 (CD)。本研究的目的是研究 MOS 主链的结构（即环状形式）和尺寸（即聚合度；DP）如何影响其味觉。我们在存在和不存在乳糖醇（一种甜味受体拮抗剂）的情况下测试了 DP 为 6、7 和 8（即分别为 α-、β- 和 γ-CD）的环糊精的味道检测。我们发现受试者可以显着水平地检测到水溶液中环糊精的味道（P < 0.05），但在乳糖醇存在的情况下无法检测到它们（P > 0.05）。这些发现表明，环糊精与其线性类似物不同，是人类甜味受体 hT1R2/hT1R3 的配体。研究结果讨论了化学结构如何影响糖类的味道。
Oligosaccharides, a subclass of complex carbohydrates, occur both naturally in foods and as a result of oral starch digestion. We have previously shown that humans can taste maltooligosaccharides (MOS) and that their detection is independent of the canonical sweet taste receptor. While MOSs most commonly occur in a linear form, they can also exist in cyclic structures, referred to as cyclodextrins (CD). The aim of this study was to investigate how the structure of the MOS backbone (i.e. cyclic form) and the size (i.e. degree of polymerization; DP) affect their taste perception. We tested taste detection of cyclodextrins with DP of 6, 7, and 8 (i.e. α-, β-, and γ-CD, respectively) in the presence and absence of lactisole, a sweet receptor antagonist. We found that subjects could detect the taste of cyclodextrins in aqueous solutions at a significant level (P< 0.05), but were not able to detect them in the presence of lactisole (P> 0.05). These findings suggest that the cyclodextrins, unlike their linear analogs, are ligands of the human sweet taste receptor, hT1R2/hT1R3. Study findings are discussed in terms of how chemical structures may contribute to tastes of saccharides.