Live vaccine trials against nocardiosis in yellowtail Seriola quinqueradiata
Live vaccine trials against nocardiosis in yellowtail Seriola quinqueradiata
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DOI：
10.1016/j.aquaculture.2006.09.006
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发表时间：
2006-12-11
期刊：
影响因子：
4.5
通讯作者：
Sakai, Masahiro
中科院分区：
文献类型：
--
作者：
Itano, Tomokazu;Kawakami, Hidemasa;Sakai, Masahiro
为了研制一种针对丝状诺卡氏菌的疫苗，将活菌N.soli、N.fluminea和N.uniformis注射到黄尾五射丝虫中。此外，鱼被一种低毒力的新冠杆菌菌株挑战，以模拟使用活疫苗的概念。注射活细胞的鱼对人工攻击有轻微的抵抗力。另一方面，在细毛虫感染中幸存下来的鱼对细毛虫的挑战表现出完全的抵抗力。这些结果表明，黄尾鱼能够诱导保护性免疫反应。(C)2006爱思唯尔B.V.保留所有紧身衣。
In an attempt to develop a vaccine against Nocardia seriolae, related species of live bacteria N. soli, N. fluminea, and N. uniformis were injected into yellowtail Seriola quinqueradiata. In addition, fish were challenged with a low virulence strain of N. seriolae to model the concept of use of a live vaccine. The fish injected with live N. soli and N. fluminea cells showed slight resistance against an artificial challenge with N. seriolae. On the other hand, the fish that survived the N. seriolae infection showed complete resistance to the N. seriolae challenge. These results suggest that protective immune responses against N. seriolae are induced in yellowtails. (c) 2006 Elsevier B.V All tights reserved.