Sleeping at the switch.
Sleeping at the switch.
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睡在开关处。
DOI：
10.7554/elife.64337
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发表时间：
2021-08-27
期刊：
影响因子：
7.7
通讯作者：
Carrier J
中科院分区：
文献类型：
--
作者：
Bouchard M;Lina JM;Gaudreault PO;Lafrenière A;Dubé J;Gosselin N;Carrier J
研究睡眠慢波在大脑可塑性、稳态调节以及衰老过程中的变化中的作用。在这里，我们解决的可能性，两种类型的慢波共存于人类。30名年轻人和29名老年人接受了一夜的多导睡眠图记录。使用转换频率，发现了具有缓慢转换的慢波（慢切换器）和具有快速转换的慢波（快切换器）。慢转换者在去极化过渡期的脑电图（EEG）连通性较高，而快转换者的连通性较低，夜间消散较快。衰老与睡眠压力在缓慢和快速切换者中的时间耗散较低以及在振荡的微尺度下的EEG连接性较低相关，这表明老年人的连接网络灵活性降低。我们的研究结果表明，两种不同类型的慢波与可能不同的潜在功能共存的慢波谱。
Sleep slow waves are studied for their role in brain plasticity, homeostatic regulation, and their changes during aging. Here, we address the possibility that two types of slow waves co-exist in humans. Thirty young and 29 older adults underwent a night of polysomnographic recordings. Using the transition frequency, slow waves with a slow transition (slow switchers) and those with a fast transition (fast switchers) were discovered. Slow switchers had a high electroencephalography (EEG) connectivity along their depolarization transition while fast switchers had a lower connectivity dynamics and dissipated faster during the night. Aging was associated with lower temporal dissipation of sleep pressure in slow and fast switchers and lower EEG connectivity at the microscale of the oscillations, suggesting a decreased flexibility in the connectivity network of older individuals. Our findings show that two different types of slow waves with possible distinct underlying functions coexist in the slow wave spectrum.