Comparison of sex-steroid synthesis between neonatal and adult rat hippocampus
Comparison of sex-steroid synthesis between neonatal and adult rat hippocampus
复制标题
DOI：
10.1016/j.bbrc.2009.05.005
复制
发表时间：
2009-07-17
影响因子：
3.1
通讯作者：
Kawato, Suguru
中科院分区：
文献类型：
--
作者：
Higo, Shimpei;Hojo, Yasushi;Kawato, Suguru
海马体性类固醇的合成在新生阶段被认为比成年阶段活跃得多。然而，这两个阶段之间的详细比较还没有得到论证。在这里，我们进行了类固醇生成酶的mRNA水平和类固醇代谢率在这两个阶段的海马区进行了比较。P450(17α)、17β或3β-羟基类固醇脱氢酶或P450arom在新生儿阶段的相对表达水平大约是成人期的1.3-1.5倍。在新生儿阶段，性类固醇代谢(从脱氢表雄酮到雌二醇)的速度比成年阶段快2-7倍(取决于不同的步骤)。总而言之，新生儿类固醇合成比成人类固醇合成更为活跃。(C)2009 Elsevier Inc.保留所有权利。
Sex-steroid synthesis in the hippocampus had been thought to be much more active at the neonatal stage than at the adult stage. However, the detailed comparison between these two stages had not been demonstrated yet. Here we performed the comparison about the mRNA level of steroidogenic enzymes and the rate of steroid metabolism between these two stages of the hippocampus. The relative expression level of P450(17 alpha), 17 beta- or 3 beta-hydroxysteroid dehydrogenase, or P450arom was approximately 1.3-1.5-fold higher at the neonatal than at the adult stage. The rate of sex-steroid metabolism (from dehydroepiandrosterone to estradiol) was 2-7-fold (depending on different steps) more rapid at the neonatal than at the adult stage. Taken together, neonatal steroidogenesis is moderately more active than adult steroidogenesis. (C) 2009 Elsevier Inc. All rights reserved.